The clinical research infrastructure at the Wyss Institute facilitates informed and accelerated product development. Human clinical studies are a unique and critical facet of the Institute and, together with animal studies, are central to our technology development and translational efforts. We have vast ongoing clinical research efforts, with more than 50 active human and preclinical/non-human subjects research studies.
Our clinical research team supports the clinical studies at the Institute and across our collaborating institutions, ensuring compliance with Good Clinical Practice and other applicable federal and university regulations. The team is the central liaison between study personnel, participants, the Institutional Review Board (IRB), and the Committee on Microbiological Safety (COMS). Our staff also provide assistance with study design, protocol implementation, coordination, training on clinical protocols, data collection, participant enrollment and maintenance of study documentation and files. These capabilities are a driving force for the successful translation of research and laboratory innovations at the Wyss Institute.
Similar to human clinical trials, the Institute recognizes that pre-clinical animal work is equally important. Our pre-clinical animal resources include consultation in study design, direct veterinary and technical support, and species-specific training in experimental techniques. The infrastructure of the Wyss Institute ensures that animals are used judiciously and that their role in science is refined, and well-reasoned. Consistent with the 3R’s (replacement, reduction and refinement) of animals in research, the Wyss champions technologies that one day could become alternatives to the use of animals for scientific purposes.
Participate in Clinical Studies
Health & Safety
The Wyss Institute's laboratory safety support and training are provided by Harvard University’s Environmental Health & Safety (EH&S) office and the Wyss Institute’s Lab Manager and Biosafety Officer. The Harvard EH&S website (http://www.ehs.harvard.edu/) provides guidance documents, help sheets, and numerous resources searchable by area, (e.g., Buildings & Facilities, Emergency Management, Laboratories), services, program and resource type.
Environmental Health & Safety
The Wyss Institute promotes a team driven, yet individually responsible, safety culture that executive management ensures is an inherent component of all the exemplary science performed here. Wyss EH&S is dedicated to providing a safe and healthy work environment within the institute and the surrounding environments by encouraging and implementing best safety practices to minimize incident occurrences, providing emergency responses, responsibly managing hazardous material from acquisition to disposal, and ensuring regulatory compliance.
Annual Environmental Health & Safety Training
In accordance with Occupational Safety and Health Administration (OSHA) requirements, all employees of the Wyss Institute are required to complete EH&S training annually. In addition, all collaborators who request access to the Wyss facilities must also complete the online EH&S training.
Once you have been added to the EH&S training roster, access the online training modules before signing in to the Harvard Training Portal (HTP).
For access to the Wyss facilities, contact:
- For any emergency, contact the Harvard University Police Department (HUPD). Longwood: 617.432.1212 | Cambridge: 617.495.1212
- For medical emergencies, call 911 then HUPD with the exact location of the emergency.
- For 24/7 laboratory emergency response (i.e. chemical or biological spill), call University Operations at 617.495.5560
Safety Data Sheets (SDSs)
- Safety Data Sheets (SDSs) are prepared by manufacturers to summarize the health and safety information relating to their products.
- To obtain SDSs, consult the manufacturer’s website or visit the EH&S SDS webpage where you can access the ChemWatch database of more than 13 million SDSs.
Software, Data & Toolkits
The Wyss Institute has compiled a list of open-source software, data, and toolkits that are available to the public.
caDNAno is open-source software for the design of three-dimensional DNA origami nanostructures. It was written with the goal of providing a simple and user-friendly interface to facilitate a process that can be complex and error-prone.
A team of researchers led by Wyss Associate Faculty member Wesley Wong, Ph.D. has created inexpensive tools for probing molecular interactions. Called DNA “nanoswitches”, the new nanoscale tools are made from strands of DNA that report how molecules behave, enabling biological measurements to be made by almost anyone, using only commonly available laboratory reagents.
Join the Wyss Institute Popup Challenge, a design contest based around the laminate design techniques outlined at popupcad.org. popupCAD is a program which makes it incredibly easy to make multi-layer design files. popupCAD designs generally end up being cut out by a laser cutter, 3D printer, or CNC Mill.
PhysioNet offers free access to large collections of recorded physiologic signals and related open-source software. The PhysioNet web site is a public service of the PhysioNet Resource funded by the National Institutes of Health’s NIBIB and NIGMS.
The Wyss Institute Core Faculty drive forward the field of Biologically Inspired Engineering by publishing numerous high impact publications in a wide range of areas. Reports have been published in journals that cover numerous scientific disciplines including synthetic biology, developmental biology, physiology, materials science, nanotechnology, chemistry, physicals, mechanical engineering, robotics, electrical engineering, computer science, and cancer research among others.