Wyss InstituteHealthy Aging – Wyss Institute

Reversing age by reprogramming gene expression networks

Jessica Leff — Wed, 14 Oct 2026 14:55:28 +0000

By Benjamin Boettner (BOSTON) — Every organ and tissue progressively loses function and integrity as it ages. In fact, researchers have identified “hallmarks of aging” that not only present specific processes impacted by age, but are also thought of as levers that, if successfully targeted, could help turn back the aging clock and result in tissue rejuvenation. In 2006…

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Buying time: A medical breakthrough in stroke treatment

Jessica Leff — Wed, 12 Aug 2026 13:33:27 +0000

When a stroke strikes, every minute matters. Science has traditionally approached stroke as a race against time. But rather than racing faster, what if we could instead slow the damage down? Join host Shahni Wellington as she explores groundbreaking research aimed at buying more time for stroke patients, particularly those in rural and regional communities. In this episode, she talks with Dr.

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Harkamal (Hark) Jhajj on rewiring immune cells to repair fractured bones

Jessica Leff — Wed, 29 Jul 2026 13:52:41 +0000

The Humans of the Wyss (HOW) series features members of the Wyss community discussing their work, the influences that shape them as professionals, and their collaborations at the Wyss Institute and beyond. Harkamal (Hark) Jhajj is always climbing physical and metaphorical mountains. In his spare time, he loves doing physical activities and exploring nature by hiking and visiting national parks.

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TIB: Tolerance Inducing Biomaterials for Regulatory T Cells

Jessica Leff — Mon, 06 Jul 2026 17:38:18 +0000

Tissue regeneration following injuries and degenerative processes benefits greatly from the activity of regulatory T cells (Tregs) that help balance the immune system, which senses, regulates, and helps restore tissue environments following injury and in disease. In fact, immune therapies using Tregs have shown first promise in treating a wider variety of diseases. However…

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The Wyss Institute’s 2026-2027 Validation Projects

Jessica Leff — Mon, 06 Jul 2026 14:00:41 +0000

Each year, the Wyss Institute’s Validation Project program identifies technologies that are ready to move beyond discovery and into the validation phase. Through dedicated funding, technical resources, business development support, market research, and engagement with clinicians, investors, industry experts, and key opinion leaders, the program helps research teams de-risk high-impact innovations…

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How federal funds fuel life-saving innovation

Jessica Leff — Thu, 20 Nov 2025 17:49:40 +0000

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Crossing the barrier: Wyss Brain Targeting Program is delivering on its promise

Seth Kroll — Wed, 22 Oct 2025 13:18:46 +0000

By Seth Kroll (BOSTON) — Launched in 2019 as an ambitious idea, the Wyss Brain Targeting Program was designed to address a critical challenge in neuroscience and brain health: how to safely and effectively deliver drugs across the blood-brain barrier (BBB). The BBB is a tightly regulated gateway that protects the brain from toxins and pathogens but also prevents nearly all large-molecule drugs…

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GeneSkin: A Novel mRNA Therapy for Skin and Hair Rejuvenation

Jessica Leff — Thu, 25 Sep 2025 13:44:27 +0000

More than 1.9 billion people worldwide suffer from some form of skin disease or cosmetic issue, including acne, eczema, scars, wrinkles, and hair loss. However, dermatological research has only brought limited therapeutic progress for skin rejuvenation, scar treatment, and hair loss in recent decades. While many of these conditions share a common root in the declining function of the skin’s stem…

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Recapitulating egg and sperm development in the dish

Jessica Leff — Fri, 15 Aug 2025 17:55:46 +0000

By Benjamin Boettner (BOSTON) — More than one-sixth of adults around the world experience infertility in their lifetime. There is a high unmet need not only for increased access to affordable, high-quality fertility care for those in need but, importantly, also for new biomedical solutions that can address the root causes of infertility. Some of the earliest causes of infertility go back to…

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The Wyss Institute’s 2025-2026 Validation Projects

Jessica Leff — Thu, 14 Aug 2025 15:00:53 +0000

Throughout recent years, the Wyss’ Validation Project mechanism has proven to be a highly valuable instrument for selecting and kick-starting projects with early potential for positive impact on healthcare and the environment. Reaching deep into areas with major unmet needs across the diverse Grand Challenges laid out by the Institute, the newly selected projects are driven by multi-talented teams…

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