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Development of Blood-Brain Barrier Biomimetic Microsystems

The Wyss Institute for Biologically Inspired Engineering at Harvard University invites applications for a postdoctoral fellow position in the Biomimetic Microsystems platform. The mission of the Wyss Institute is to discover the engineering principles that Nature uses to build living things; to pursue the high-risk research that is fundamental to advance this effort; and to harness these insights to create biologically-inspired materials and devices to advance human health and improve the environment – thereby revolutionizing clinical medicine and creating a more sustainable world.

We seek outstanding postdoctoral applicants with expertise in blood-brain barrier biology and physiology and/or knowledge of targeted delivery across the vascular endothelium to join an interdisciplinary team of biologists and engineers for the development of novel delivery peptides to target diseases of the brain. The applicant will use in vitro “organ-on-chip” microsystems technologies to study and model the blood brain barrier as well as identify and validate peptides for targeted delivery. Applicants are expected to hold a Ph.D. or M.D. and have a proven record of high quality publications in blood brain barrier and/or targeted drug delivery. Strong interest in contributing to multidisciplinary teams (engineers, biologists/physiologists, clinicians) is critical for this position. Expertise in in vitro culture of primary human cells, as well as knowledge of basic molecular and cell biology concepts and techniques is a must. Experience with iPS-derived stem cell culture/differentiation, phage display techniques, and animal models would be beneficial but not necessary.

The ideal candidate would bring expertise in blood brain barrier biology, physiology, and pathophysiology, with an interest in applying this expertise in combination with modern bioengineering and targeted drug delivery practices. This postdoctoral fellow is expected to develop and lead an interdisciplinary research project aimed at creating microengineered “organ-on-chip” models, simulating human diseases and exploring their use in drug discovery and targeted delivery applications.

Applications, assembled as single PDF files, should contain a complete resume, cover letter describing research interests and goals, full list of publications, copies of up to three relevant scientific papers, as well as the names and contact information of three references (expected to provide letters of recommendation). Applications should be sent to using the subject line “BLOOD BRAIN BARRIER TARGETED DELIVERY APPLICATION.”

Harvard University is an Equal Opportunity/Affirmative Action employer and applications from women and minority candidates are strongly encouraged.

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