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Technologies 3

• DoriVac: DNA Origami-Based Vaccines for Combination Immunotherapy
  Personalized cancer and infectious disease vaccine platform harnessing DNA nanotechnology to control the co-delivery and co-presentation of tumor antigen and adjuvant ligands to immune cells with nanoscale precision. This approach has potential to trigger enhanced immune responses against tumors and infectious pathogens.
• Crisscross Nanoseed Detection: Nanotechnology-Powered Infectious Disease Diagnostics
  This nanotech-based diagnostic platform uses a unique nucleation mechanism that assembles a DNA "nanoseed" in the presence of a pathogen-derived biomarker that then is amplified within 15 minutes to create a signal for easy detection. It is highly robust, and cost-effective, and can be adapted to detect a variety of biomarkers.
• Implantable Cancer Vaccine
  The implantable cancer vaccine is an aspirin-sized disc that is implanted under the skin and serves as an artificial lymph node, recruiting and training a patient's own immune cells to find and kill their cancer cells. It was validated in a Phase I clinical trial at the Wyss Institute, and is currently being developed by Novartis to treat melanoma.

Collaborations 1

• i3 Center: Biomaterials to Create T Cell Immunity
  Cancer immunologists and biological engineers are developing new biomaterials-based approaches to develop new anti-cancer immunotherapies for treatment-resistant cancers.

News 18

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• Press Release
  
  DNA origami-based vaccines toward safe and highly-effective precision cancer immunotherapy
  March 15, 2024
• Research Spotlights
  
  Ultrasensitive Blood Test Detects ‘Pan-Cancer’ Biomarker
  October 6, 2023
• Press Release
  
  CAR-T cell cancer immunotherapy gets personal
  February 10, 2023

Multimedia 4

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  Video/Animation
  Seed-dependent crisscross DNA-origami slats
  This animation explains how the newly invented crisscross origami method can be used to build functionalized micron-scale DNA megastructures composed of many unique DNA origami “slats,” each with their own complexity and interactive properties. Credit: Wyss Institute at Harvard University

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  Video/Animation
  DoriVac: Square Block DNA Origami Vaccine
  This animation explains how DoriVac leverages DNA origami nanotechnology and immune activators to stimulate stronger and long-lasting immune responses against cancer and potentially infectious diseases. Credit: Wyss Institute at Harvard University

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  Audio/Podcast
  Disruptive: Cancer Vaccine & Hydrogel Drug Delivery
  In this episode of Disruptive, Wyss Founding Core Faculty Member Dave Mooney discusses programmable nanomaterials approaches to fighting disease. Mooney explains how a cancer vaccine, developed by his team and currently in a clinical trial at the Dana-Farber Cancer Institute, can train one’s own immune system to target specific cancer cells. He also describes the...

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  Video/Animation
  Introduction to Implantable Cancer Vaccine
  What if we could prevent and treat cancer with a simple vaccine? Credit: Wyss Institute at Harvard University