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Alexandra Sontheimer-Phelps, Ph.D.

Staff Scientist

Alexandra Sontheimer-Phelps, Ph.D.

Alexandra is a cell biologist by training, working on the organs-on-chip platform to develop better in vitro models for gastrointestinal diseases. On the Cancer Research UK Grand Challenge, she is investigating with internal and external collaborators how chronic inflammation of the colon and esophagus progresses to the development of inflammation-associated cancers. Her current priorities include identifying what role the stroma plays in the disease progression, determining how we can therapeutically normalize the stroma to prevent or revert the progression from inflammation to cancer, and identifying biomarkers for patients likely to progress from chronic inflammation to cancer leveraging organs-on-chip.

While Alexandra was obtaining her Ph.D. from the University of Freiburg in Germany, she was a visiting student in Don Inber’s lab at the Wyss Institute,  conducting research developing a human Colon-on-Chip model to investigate mucus physiology and pathophysiology.

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