MacDonald’s research interests focus on the development and characterization of well-defined protein conjugates for their application in nanodevices. Prior to joining the Wyss, he worked at Pfizer, where he worked on the synthesis of novel small molecule therapeutics and the development of antibody-drug conjugates for the treatment of diabetes and cancer, respectively. His academic research concentrated on the development of site-specific protein modification reactions for the construction of protein-based materials for small molecule detection and targeting imaging applications. Jim received a B.S. in biochemistry and molecular biology from the University of Richmond and a Ph.D. in chemistry from the University of California, Berkeley.