The Wu laboratory studies how chromosome behavior and positioning influence genome function and evolution, with implications for gene regulation, genome stability, and human diseases. Using genetic, molecular biological, computational, and imaging tools, we examine structural and functional aspects of chromosome organization, with particular emphasis on the relationship between homologous chromosomes, such as homolog pairing, as well as genome compartmentalization, centromeres, and sequence ultraconservation. As part of these efforts, her group has developed a variety of technologies, ranging from strategies that facilitate genome engineering to Hi-FISH for high-throughput screening of entire genomes using fluorescent in situ hybridization (FISH), the Oligopaint method for in situ visualization of DNA and RNA, HOPs for distinguishing maternal and paternal chromosomes, and OligoSTORM and OligoDNA-PAINT for super-resolution via single-molecule localization microscopy.
Ting Wu is also a Professor of Genetics at Harvard Medical School, Director of the Consortium for Space Genetics, and Director of the Personal Genetics Education Project (pgEd). She is the recipient of an NIH Director’s 2012 Pioneer Award for her laboratory’s work on genome organization and an NIH Director’s 2016 Transformative Research Award for work on sequence ultraconservation as a strategy for maintaining genome integrity.