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Blood Clot Dx

admin — Wed, 09 Jul 2025 17:00:40 +0000

Blood clots can arise anywhere in the body, blocking blood flow and causing pain and other symptoms. The most serious types of clots, called deep vein thrombosis (DVT), typically form in the veins in the legs, and can break off and become lodged in a lung. This can cause a pulmonary embolism (PE), which is when blood flow to the lungs is prevented and can be fatal. The symptoms of PE resemble…

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Mice Don’t Menstruate: Reimagining Women’s Health Using Organ Chips with Dr. Donald Ingber

Jessica Leff — Wed, 08 May 2024 13:05:03 +0000

In this episode, host Sharon Kedar, Co-Founder of Northpond Ventures, is joined by Dr. Donald Ingber, Founding Director at Wyss Institute for Biologically Inspired Engineering at Harvard University. Dr. Ingber’s commitment to following his passion has led him to countless medical and technological breakthroughs, including Organ Chip technology. These incredible chips recreate the structure and…

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Paper-Based Diagnostics

admin — Wed, 01 May 2024 00:34:41 +0000

With the imminent threat of new pandemics and frequent disease outbreaks exemplified by the recent Ebola and Zika epidemics, there is a growing need for low-cost, easily deployable and simple-to-use diagnostic tools. The Wyss Institute has developed paper-based synthetic gene networks as a next generation diagnostic technology for use in global healthcare crises and patient care. This new type of…

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Passive Directional Valve Technology: Towards More User-friendly and Accessible Microfluidic Devices for Diagnostic and Research Applications

Jessica Leff — Fri, 12 Jan 2024 17:42:46 +0000

Automated fluid-transporting and processing systems that function on the scale of micrometers (microfluidic systems) are becoming increasingly important for advancing various diagnostic, drug fabrication and delivery, and tissue engineering applications. Efforts to create smaller microfluidic devices with functionalities realized at larger scales rely heavily on valves to enable the regulated…

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Bridging science, engineering, and art: from mechanobiology to Human Organs-on-Chips

Jessica Leff — Thu, 27 Jul 2023 17:49:31 +0000

In this Marsilius Lecture, Wyss Founding Director Don Ingber shares his personal path from a serendipitous experience in an undergraduate art class that led to his discovery of how living cells are constructed using “tensegrity” architecture and how this contributed to the birth of the field of Mechanobiology to his more recent work on human Organ Chips, which offer the possibility of replacing…

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How do we make safer and more effective drugs?

Jessica Leff — Mon, 12 Jun 2023 15:14:20 +0000

Wyss researchers are using an ever-growing number of human tissue-mimicking Organ Chips to improve and accelerate the drug development process for a wide number of unmet diseases – and understand what causes them to erupt. More recently, they added a human Vagina Chip and personalized Barrett’s esophagus Chip to their arsenal, and created in vitro models of inflammatory bowel disease in children…

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Barrett’s esophagus modeled in a human Organ Chip

Jessica Leff — Thu, 08 Jun 2023 14:55:25 +0000

By Benjamin Boettner (BOSTON) — Acid reflux, the backwash of stomach acid into the throat, or esophagus, is something that people many experience occasionally. But when it happens repeatedly and becomes a chronic problem, it can result in “Barrett’s esophagus” (BE), a condition in which cells in the epithelial lining of the esophagus appear to transform into stomach or intestine cells.

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Adama Sesay on Solving Problems with Sensors and Microsystems

Jessica Leff — Thu, 30 Mar 2023 13:07:13 +0000

The Humans of the Wyss (HOW) series features members of the Wyss community discussing their work, the influences that shape them as scientists, and their collaborations at the Wyss Institute and beyond. If you had asked Adama Sesay as a child what she wanted to be when she grew up, the answer would have been a doctor, an architect, and a firefighter. Now a Senior Engineer specializing in…

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Cystic fibrosis faithfully modeled in a human Lung Airway Chip

Jessica Leff — Fri, 19 Nov 2021 15:58:31 +0000

By Benjamin Boettner (BOSTON) — The inherited progressive disorder cystic fibrosis (CF) causes severe damage to the lungs, and other tissues in the body by affecting the cells that produce mucus, sweat, and digestive juices. In individuals carrying mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which encodes an ion channel controlling the flow of ions and…

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Predicting influenza virus evolution in a human Lung Airway Chip

Jessica Leff — Mon, 20 Sep 2021 13:19:07 +0000

By Benjamin Boettner (BOSTON) – Influenza virus was the cause of the flu pandemic of 1918 that killed over 20 million people world-wide, and different variants continue to cause new epidemic flu outbreaks every year that threaten the health and livelihoods of many. The Centers for Disease Control and Intervention (CDC) estimate that influenza has resulted in between 9 million and 45 million…

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