Wyss InstituteOrgans on Chips – Wyss Institute

Fireside Chat with Dr. Donald Ingber – Raif Ali Dinçkök Student Forum at the Mehrotra Institute

Jessica Leff — Fri, 06 Nov 2026 17:51:27 +0000

In this fireside chat, Donald Ingber shares what a lifetime spent inventing at the border of biology and engineering has taught him: how nature’s own designs can solve humanity’s hardest problems, why the greatest breakthroughs come from connecting fields no one thought to combine, and where bioinspired science is taking the future of medicine. Ingber is the Founding Director of the Wyss…

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Bay Area Lyme Foundation supports Wyss Institute researchers’ quest to restore patients’ ability to fight back against Lyme Disease

Jessica Leff — Fri, 30 Oct 2026 12:43:48 +0000

By Benjamin Boettner (BOSTON) — A year of generous funding by the Bay Area Lyme Foundation enabled a Wyss Institute project that aims to identify novel therapeutic strategies for acute and chronic Lyme disease (Lyme) to proceed into new and potentially therapeutic territory. Girija Goyal, Ph.D., Director of Bioinspired Therapeutics at the Wyss Institute and her team were honored at the recent…

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Ernest Aguinam on understanding the immune system to help patients with radiation injury and chronic Lyme

Jessica Leff — Tue, 29 Sep 2026 13:13:50 +0000

The Humans of the Wyss (HOW) series features members of the Wyss community discussing their work, the influences that shape them as professionals, and their collaborations at the Wyss Institute and beyond. How is developing therapeutics like writing a song? Ernest Aguinam starts with a hypothesis or a new lyric, tests variables, like tempo or a new compound, and in the end, aims for a certain…

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Cutting to the Case: Don Ingber

Jessica Leff — Fri, 11 Sep 2026 13:56:59 +0000

Don Ingber, M.D., Ph.D., is the Founding Director of Harvard University’s Wyss Institute for Biologically Inspired Engineering and a pioneer of organ-on-a-chip technology. In this episode of Cutting to the Case, Ingber and host Cameron Sabet discuss how he helped create organs-on-chips, what these systems can teach us that traditional models cannot, and how biologically inspired engineering…

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Accelerating biomedical innovation with AI through collaborative iteration

Mariel Schoen — Thu, 06 Aug 2026 13:35:25 +0000

By Mariel Schoen Long before ChatGPT brought Artificial Intelligence (AI) into the public spotlight, scientists at the Wyss Institute were using AI-driven computational approaches, including machine learning and deep learning, to solve complex biomedical problems and develop new technology innovations. Today, while much of the field is racing to build larger models, the Institute is focused…

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Recapitulating intramuscular vaccination with mRNA vaccines in patient-specific Lymphoid Organ Chips

Mariel Schoen — Fri, 17 Jul 2026 13:55:40 +0000

By Benjamin Boettner (BOSTON) — The protective abilities of the Moderna and BioNTech mRNA vaccines developed against COVID-19 saved millions of lives during the pandemic and put this platform technology in the spotlight of vaccine research. By now, mRNA vaccines for other infectious diseases, such as influenza, RSV, and HIV are being tested in clinical trials and highly anticipated.

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The Wyss Institute’s 2026-2027 Validation Projects

Jessica Leff — Mon, 06 Jul 2026 14:00:41 +0000

Each year, the Wyss Institute’s Validation Project program identifies technologies that are ready to move beyond discovery and into the validation phase. Through dedicated funding, technical resources, business development support, market research, and engagement with clinicians, investors, industry experts, and key opinion leaders, the program helps research teams de-risk high-impact innovations…

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Machine-learning how to overcome antibiotic-resistant gonorrhea

Jessica Leff — Wed, 17 Jun 2026 17:55:26 +0000

By Benjamin Boettner (BOSTON) — With tens of millions of annual cases, gonorrhea is the second most frequently reported sexually transmitted infection (STI). In the U.S. alone, over 600,000 cases are reported each year. If left untreated, gonorrhea can result in severe reproductive health issues, including infertility in both women and men, and pelvic inflammatory disease.

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David Chou on keeping people safe from radiation on Earth and beyond

Jessica Leff — Thu, 28 May 2026 13:00:27 +0000

The Humans of the Wyss (HOW) series features members of the Wyss community discussing their work, the influences that shape them as professionals, and their collaborations at the Wyss Institute and beyond. David Chou’s work is literally out of this world! In addition to identifying radiation countermeasures for use on Earth, he is part of the AVATAR project, which aims to understand how humans…

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Decoding inflammatory bowel disease – on a chip

Jessica Leff — Thu, 21 May 2026 09:30:43 +0000

By Benjamin Boettner (BOSTON) — Inflammatory bowel disease (IBD), which comprises the inflammatory conditions Crohn’s disease and ulcerative colitis, affects about 1.6 million Americans, many of whom cannot be effectively treated. This is mostly due to a lack of understanding of what exactly causes the increased inflammation, fibrosis, and compromised intestinal barrier that underlie this…

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