Wyss InstituteOrgans on Chips – Wyss Institute https://wyss.harvard.edu Wyss Institute at Harvard Fri, 05 Jun 2026 19:31:09 +0000 en-US hourly 1 https://wordpress.org/?v=6.7.1 David Chou on keeping people safe from radiation on Earth and beyond https://wyss.harvard.edu/news/humans-of-the-wyss-david-chou-on-keeping-people-safe-from-radiation-on-earth-and-beyond/ Thu, 28 May 2026 13:00:27 +0000 https://wyss.harvard.edu/?p=45523 The Humans of the Wyss (HOW) series features members of the Wyss community discussing their work, the influences that shape them as professionals, and their collaborations at the Wyss Institute and beyond. David Chou’s work is literally out of this world! In addition to identifying radiation countermeasures for use on Earth, he is part of the AVATAR project, which aims to understand how humans…

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]]> https://wyss.harvard.edu/news/humans-of-the-wyss-david-chou-on-keeping-people-safe-from-radiation-on-earth-and-beyond/ Studying astronaut cells in Organ Chips will inform medical strategies for future long-duration missions to Mars and beyond. The findings could also contribute to biomedical advancements for patients on Earth, such as cancer treatments and pharmaceuticals. Credit: Wyss Institute at Harvard University. https://wyss-prod.imgix.net/app/uploads/2026/04/08174412/NASA-Bonemarrow-Chips-03443_David-Chou-Holding-Chip-scaled.jpg?auto=format%2Ccompress&crop=faces%2Centropy&fit=crop&h=400&q=50&w=300&s=bef790204e2d347f30adce2ce3c3d5a5"/> Decoding inflammatory bowel disease – on a chip https://wyss.harvard.edu/news/decoding-inflammatory-bowel-disease-on-a-chip/ Thu, 21 May 2026 09:30:43 +0000 https://wyss.harvard.edu/?p=45488 Replication of patient- and sex-specific hallmarks of IBD in a human organ chip reveals stromal fibroblasts as drivers of inflammation, fibrosis, and enhanced cancer risk By Benjamin Boettner (BOSTON) — Inflammatory bowel disease (IBD), which comprises the inflammatory conditions Crohn’s disease and ulcerative colitis, affects about 1.6 million Americans, many of whom cannot be effectively treated. This is mostly due to a lack of understanding of what exactly causes the increased inflammation, fibrosis, and compromised intestinal barrier that underlie this…

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]]> https://wyss.harvard.edu/news/decoding-inflammatory-bowel-disease-on-a-chip/ https://wyss-prod.imgix.net/app/uploads/2026/05/20121105/Colon-Chip.jpg?auto=format%2Ccompress&crop=faces%2Centropy&fit=crop&h=400&q=50&w=300&s=c60ba1aa68dd5c86bf69c58c19a8c841"/> Multidisciplinary Wyss team receives 2026 Lush Prize Science Award https://wyss.harvard.edu/news/multidisciplinary-wyss-team-receives-2026-lush-prize-science-award/ Mon, 18 May 2026 18:30:48 +0000 https://wyss.harvard.edu/?p=45467 Recognition highlights the growing impact of Organ Chip technology in reducing animal testing in biomedical and women’s health research (BOSTON) — The Wyss Institute for Biologically Inspired Engineering at Harvard University is proud to announce that the Biosensing, Microfluidics, and Microsystems team, led by Wyss Senior Engineer Adama Sesay, Ph.D., together with the Female Reproductive Health team, has received the 2026 Lush Science Prize. The prize recognizes their work developing next-generation, sensor-integrated human Organ…

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]]> https://wyss.harvard.edu/news/multidisciplinary-wyss-team-receives-2026-lush-prize-science-award/ Wyss Research Scholar Zoheh Izadifar (left), a former Postdoctoral Fellow in the lab of Wyss Founding Director Donald Ingber, and now an Assistant Professor at Boston Children’s Hospital and Harvard Medical School, received the award on behalf of the Wyss teams during the Lush Prize award ceremony, held and livestreamed on May 12 in London. This photo shows her next to jury member Ellen Fritsche (right), Director of the Swiss Centre for Applied Human Toxicology (SCAHT) affiliated to the University of Basel. Credit: Wyss Institute at Harvard University https://wyss-prod.imgix.net/app/uploads/2026/05/18113142/Zohreh-Izadifar-Science-LP26_Ellen-Fritsche-scaled-e1779118388548.jpg?auto=format%2Ccompress&crop=faces%2Centropy&fit=crop&h=400&q=50&w=300&s=a7846fa4b4163e138d93bb0cd4969b75"/> Next-Gen Toxicology: Inside the Organ Chip Revolution with Donald Ingber https://wyss.harvard.edu/media-post/next-gen-toxicology-inside-the-organ-chip-revolution-with-donald-ingber/ Wed, 06 May 2026 17:06:35 +0000 https://wyss.harvard.edu/?post_type=media_post&p=45389 In this episode of ToxChats, hosts Lauren Walker and Sarah Benjamin sit down with the groundbreaking Donald Ingber—visionary scientist, engineer, and Founding Director of the Wyss Institute. Ingber shares how his unique path through medicine, biology, and design converged to spark breakthroughs such as human Organ Chips—systems that are redefining toxicology, drug development, and disease modeling.

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]]> https://wyss.harvard.edu/media-post/next-gen-toxicology-inside-the-organ-chip-revolution-with-donald-ingber/ Founding Director Donald Ingber. Credit: Wyss Institute at Harvard University https://wyss-prod.imgix.net/app/uploads/2016/08/05095242/Donald_Ingber_headshot_1500x1000.jpg?auto=format%2Ccompress&crop=faces%2Centropy&fit=crop&h=400&q=50&w=300&s=f86daa58baa3ae0c80720f0ca99dc64a"/> 20-ish Questions with Donald E. Ingber https://wyss.harvard.edu/media-post/20-ish-questions-with-donald-e-ingber/ Fri, 01 May 2026 12:00:26 +0000 https://wyss.harvard.edu/?post_type=media_post&p=45288 20-ish Questions shows a different side of Wyss Institute faculty, touching on aspects of their personal life, hobbies, interests, as well as their research. This round follows Donald E. Ingber, the Founding Director and a Core Faculty member at the Wyss Institute. He is also the Judah Folkman Professor of Vascular Biology at Harvard Medical School and Boston Children’s Hospital, as well as the…

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]]> https://wyss.harvard.edu/media-post/20-ish-questions-with-donald-e-ingber/ https://wyss-prod.imgix.net/app/uploads/2026/04/16114014/THUMBNAIL_20-ish-Questions-with-Don-Ingber_No-Text-scaled.jpg?auto=format%2Ccompress&crop=faces%2Centropy&fit=crop&h=400&q=50&w=300&s=9411b022404b9cf8eb8c9560744418dd"/> Wyss Institute technologies enable breakthrough in astronaut health research aboard NASA’s Artemis II mission https://wyss.harvard.edu/news/wyss-institute-technologies-enable-breakthrough-in-astronaut-health-research-aboard-nasas-artemis-ii-mission/ Thu, 09 Apr 2026 14:55:20 +0000 https://wyss.harvard.edu/?p=45228 Wyss Institute-enabled Organ Chip “avatars” will provide insights into astronaut health risks and provide a tool for future discovery of countermeasures necessary for travel to the Moon and beyond By Alexandra Jirstrand (BOSTON) – Launched on April 1, 2026, Artemis II is a historic, approximately 10-day lunar flyby mission that is sending four astronauts farther into space than any humans have traveled since the Apollo era, marking a critical step toward sustained lunar exploration and future missions to Mars. The Wyss Institute for Biologically Inspired Engineering at Harvard…

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]]> https://wyss.harvard.edu/news/wyss-institute-technologies-enable-breakthrough-in-astronaut-health-research-aboard-nasas-artemis-ii-mission/ Using Organ Chips containing astronaut cells, Wyss Institute and Emulate researchers will examine how radiation and microgravity impact human tissue. Credit: Wyss Institute at Harvard University https://wyss-prod.imgix.net/app/uploads/2026/04/08174051/NASA-Bonemarrow-Chips-03480_Chip-on-Microscope-scaled.jpg?auto=format%2Ccompress&crop=faces%2Centropy&fit=crop&h=400&q=50&w=300&s=1f2bbd476766a3827d203d14fedb5a30"/> Building protection against infectious diseases with nanostructured vaccines https://wyss.harvard.edu/news/building-protection-against-infectious-diseases-with-nanostructured-vaccines/ Wed, 11 Mar 2026 12:56:44 +0000 https://wyss.harvard.edu/?p=45012 Wyss Institute’s DoriVac combined vaccine and adjuvant technology uses nanoscale precision enabled by DNA origami to induce broad immunity against infectious viruses By Benjamin Boettner (BOSTON) — The COVID-19 pandemic brought messenger RNA (mRNA) vaccines to the forefront of global health care. After their clinical trial stages, the first COVID-19 mRNA vaccine was administered on 8 December 2020 and mathematical models suggest that mRNA vaccines prevented at least 14.4 million deaths from COVID-19 in the first year alone.

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]]> https://wyss.harvard.edu/news/building-protection-against-infectious-diseases-with-nanostructured-vaccines/ https://wyss-prod.imgix.net/app/uploads/2022/10/19140258/banner-image-DoriVac.jpg?auto=format%2Ccompress&crop=faces%2Centropy&fit=crop&h=400&q=50&w=300&s=02c46a8a5e23e0c41c361cb65f4eb81c"/> AVATARs for Astronaut Health Are Heading to Space! https://wyss.harvard.edu/media-post/avatars-for-astronaut-health-are-heading-to-space/ Thu, 05 Feb 2026 15:04:20 +0000 https://wyss.harvard.edu/?post_type=media_post&p=44790 NASA’s AVATAR experiment is flying aboard Artemis II to study how deep space affects human health. Using Organ Chips containing astronaut cells, Emulate and Wyss Institute researchers will examine how radiation and microgravity impact human tissue. This research will help inform medical strategies for future long-duration missions to Mars and beyond. The findings could also contribute to…

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]]> https://wyss.harvard.edu/media-post/avatars-for-astronaut-health-are-heading-to-space/ https://wyss-prod.imgix.net/app/uploads/2022/03/15123125/Organ-Chip-282A6210.jpg?auto=format%2Ccompress&crop=faces%2Centropy&fit=crop&h=400&q=50&w=300&s=8bef5a92861dbb7abfb350f987d9d561"/> Transforming cancer treatments through bioinspired engineering and translation https://wyss.harvard.edu/news/transforming-cancer-treatments-through-bioinspired-engineering-and-translation/ Wed, 04 Feb 2026 14:59:03 +0000 https://wyss.harvard.edu/?p=44742 Despite major advances in personalized medicine, targeted drugs, and immunotherapies, many cancers remain difficult – or impossible – to treat. Even when therapies work, they can trigger serious secondary health risks that may themselves become life-threatening. Wyss Institute researchers are tackling these challenges head-on by developing new therapies that more powerfully activate the immune…

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]]> https://wyss.harvard.edu/news/transforming-cancer-treatments-through-bioinspired-engineering-and-translation/ Abidemi Junaid holding the microfluidic chip used to monitor blood clotting. https://wyss-prod.imgix.net/app/uploads/2016/08/09145422/Abidemi-with-Hemostasis-Chip-Posed-08089-scaled.jpeg?auto=format%2Ccompress&crop=faces%2Centropy&fit=crop&h=400&q=50&w=300&s=799ada1f03931c9e36620cd1d4f32f2f"/> Toward engineering a human kidney collecting duct system https://wyss.harvard.edu/news/toward-engineering-a-human-kidney-collecting-duct-system/ Fri, 30 Jan 2026 14:50:56 +0000 https://wyss.harvard.edu/?p=44698 Newly developed method to fabricate perfusable collecting ducts of the human kidney opens the door to disease modeling, drug testing, and organ engineering By Benjamin Boettner (BOSTON) — The human kidney filters about a cup of blood every minute, removing waste, excess fluid, and toxins from it, while also regulating blood pressure, balancing important electrolytes, activating Vitamin D, and helping the body produce red blood cells. This broad range of functions is achieved in part via the kidney’s complex organization. In its outer region…

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]]> https://wyss.harvard.edu/news/toward-engineering-a-human-kidney-collecting-duct-system/ As can be seen in this close-up, engineered UB tubules bud from the central channel and branch into the surrounding matrix. Credit: Wyss Institute at Harvard University https://wyss-prod.imgix.net/app/uploads/2026/01/27145033/Budding-UB-tubules-copy.jpg?auto=format%2Ccompress&crop=faces%2Centropy&fit=crop&h=400&q=50&w=300&s=89285f076bfcbe6edbe7343007eba2bb"/>