Human Organs-on-Chips and
- Monday, Nov 25, 2013
- 10:00am - 11:00am
- Tufts Science & Technology Center - Room 136, 4 Colby Street, Medford, MA 02155
- Don Ingber, MD, Ph.D.
- Founding Director & Core Faculty Member, Platform Leader,
- Biomimetic Microsystems Wyss Institute
- Judah Folkman Professor of Vascular Biology, Harvard Medical School,
- Boston Children's Hospital
- Professor of Bioengineering, Harvard School of Engineering & Applied Sciences
Abstract: In this presentation, I will describe work we have been carrying out in the Biomimetic Microsystems and Programmable Nanomaterials platforms at the Wyss Institute for Biologically Inspired Engineering at Harvard. The goal of the first platform is to engineer human ‘Organs-on-Chips’: microfluidic devices lined by living human cells created with microchip manufacturing techniques that recapitulate organ-level functions as a way to replace animal testing for drug development. I will review recent advances we have made in development of multiple organ chips, including human lung, gut and bone marrow chips, as well related human disease models. I will also describe our ongoing efforts to engineer more than 10 different organ chips, to integrate them into a ‘human body on chips’, and to develop an automated instrument that enables real-time, molecular scale analysis of human cellular responses to pharmaceuticals, toxins and other chemicals in an organ-like context in vitro. The goal of the 2nd platform is to create multi-functional nanotechnologies for regenerative medicine and drug delivery applications, with the long-term goal of developing injectable programmable devices for biomedicine. I will describe multiple new bioinspired nanotechnologies, including a Shear-Activated Nanotherapeutic delivery system that targets drugs specifically to vascular occlusion sites.
- Tufts University, Biomedical Engineering Seminar Series