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Clinical and Translational Research Core

The Wyss Institute's Clinical and Translational Research Core (CTRC) is dedicated to facilitating all aspects of research at the Institute. From investigator-initiated to industry-sponsored, we support a wide range of pre-clinical and clinical research projects. We have created an infrastructure that provides the resources and training necessary to assist investigators at all levels of research. Our mission is to facilitate innovative projects at the Wyss, enabling our researchers and our collaborators to transform healthcare, industry, and the environment.

The CTRC provides the following resources: clinical research, pre-clinical and animal work, biosafety and lab safety.

Learn More About Our Clinical Research Studies

Health & Safety

The Wyss Institute promotes a team driven, yet individually responsible, safety culture that executive management ensures is an inherent component of all the exemplary science performed here. Wyss EH&S is dedicated to providing a safe and healthy work environment within the Institute and the surrounding environments by encouraging and implementing best safety practices to minimize incident occurrences, providing emergency responses, responsibly managing hazardous material from acquisition to disposal, and ensuring regulatory compliance.

  • Environmental Health & Safety

    The Wyss Institute’s laboratory safety support and training are provided by Harvard University’s Environmental Health & Safety (EH&S) office and the Wyss Institute’s Lab Manager and Biosafety Officer. The Harvard EH&S website provides guidance documents, help sheets, and numerous resources searchable by area, (e.g., Buildings & Facilities, Emergency Management, Laboratories), services, program and resource type.

  • Annual Environmental Health & Safety Training

    In accordance with Occupational Safety and Health Administration (OSHA) requirements, all employees of the Wyss Institute are required to complete EH&S training annually. In addition, all collaborators who request access to the Wyss facilities must also complete the online EH&S training.

    Once you have been added to the EH&S training roster, access the online training modules before signing in to the Harvard Training Portal (HTP).

    For access to the Wyss facilities, contact Simonetta Piergentili at

  • Emergency Reporting

    • For any emergency, contact the Harvard University Police Department (HUPD). Longwood: 617.432.1212 | Cambridge: 617.495.1212
    • For medical emergencies, call 911 then HUPD with the exact location of the emergency.
    • For 24/7 laboratory emergency response (i.e. chemical or biological spill), call University Operations at 617.495.5560



Software, Data & Toolkits

The Wyss Institute has compiled a list of open-source software, data, and toolkits that are available to the public.

  • caDNAno

    caDNAno is open-source software for the design of three-dimensional DNA origami nanostructures. It was written with the goal of providing a simple and user-friendly interface to facilitate a process that can be complex and error-prone.

  • DNA Nanoswitches

    A team of researchers led by Wyss Associate Faculty member Wesley Wong, Ph.D. has created inexpensive tools for probing molecular interactions. Called DNA “nanoswitches”, the new nanoscale tools are made from strands of DNA that report how molecules behave, enabling biological measurements to be made by almost anyone, using only commonly available laboratory reagents.

  • popupCAD

    Join the Wyss Institute Popup Challenge, a design contest based around the laminate design techniques outlined at popupCAD is a program which makes it incredibly easy to make multi-layer design files. popupCAD designs generally end up being cut out by a laser cutter, 3D printer, or CNC Mill.

  • PhysioNet

    PhysioNet offers free access to large collections of recorded physiologic signals and related open-source software. The PhysioNet web site is a public service of the PhysioNet Resource funded by the National Institutes of Health’s NIBIB and NIGMS.


The Wyss Institute Core Faculty drive forward the field of Biologically Inspired Engineering by publishing numerous high impact publications in a wide range of areas. Reports have been published in journals that cover numerous scientific disciplines including synthetic biology, developmental biology, physiology, materials science, nanotechnology, chemistry, physicals, mechanical engineering, robotics, electrical engineering, computer science, and cancer research among others.

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