Specialized pro-resolving mediators in airway health and disease
- Wednesday, Feb 10, 2016
- 1:00pm - 2:00pm
- 3 Blackfan Circle, room 521, Boston, MA 02115
- Bruce D. Levy, M.D.
- Associate Professor
- Pulmonary and Clinical Care Medicine
- Brigham and Women's Hospital and Harvard Medical School
Acute airway inflammation is a fundamental part of our body's immune response, but chronic or excessive inflammation can lead to several life-threatening diseases. Reducing or resolving inflammation is an active process that occurs inside us, and is directed in part by chemicals called "pro-resolving mediators". At the onset of acute inflammation, cell-to-cell interactions establish biological pathways for these pro-resolving mediators, including several other biological agents which help return the inflamed airway to a healthy state of homeostasis. Understanding these cellular and molecular mechanisms for pro-resolving mediators can provide new insights into: how our tissues respond in ways to help resolve inflammation; the pathophysiology of disease, such as how we respond to infections; as well as opportunities for therapeutic intervention.
- Rachelle Prantil-Baun, Ph.D.
- Senior Staff Scientist, Wyss Institute at Harvard University