Application Area: Liver Disease

Technologies 1

• Human Organs-on-Chips
  Organ Chips are microfluidic devices lined with living human cells for drug development, disease modeling, and personalized medicine. Launched in 2014, Wyss startup Emulate, Inc., is leveraging the Wyss Institute’s Organ Chip technology to mimic human organs in vitro, enabling faster, better, and cheaper drug development and insights into human health.

News 10

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• Community
  
  From classmates to co-founders
  April 21, 2023
• Community
  
  Luba Perry on Engineering Vascularized Tissue
  June 23, 2021
• Press Release
  
  Human Body-on-Chip platform enables in vitro prediction of drug behaviors in humans
  January 27, 2020

Multimedia 3

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  Video/Animation
  Interrogator: Human Organ-on-Chips
  This video describes the “Interrogator” instrument that can be programmed to culture up to 10 different Organ Chips and sequentially transfer fluids between their vascular channels to mimic normal human blood flow between the different organs of our body. Its integrated microscope enables the continuous monitoring of the tissues’ integrities in the individual organ chips...

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  Video/Animation
  Human Organs-On-Chips
  Wyss Institute researchers and a multidisciplinary team of collaborators have engineered microchips that recapitulate the microarchitecture and functions of living human organs, including the lung, intestine, kidney, skin, bone marrow and blood-brain barrier. These microchips, called ‘organs-on-chips’, offer a potential alternative to traditional animal testing. Each individual organ-on-chip is composed of a clear flexible polymer...

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  Video/Animation
  Introduction to Organs-on-a-Chip
  What if we could test drugs without animal models? Wyss Institute researchers and a multidisciplinary team of collaborators have engineered microchips that recapitulate the microarchitecture and functions of living human organs, including the lung, intestine, kidney, skin, bone marrow and blood-brain barrier. These microchips, called ‘organs-on-chips’, offer a potential alternative to traditional animal testing. Each...