Department: Research and Technology Development

Jobs 4

• Research Assistant II – DNA Imaging
  Research and Technology Development

  As a Research Assistant within the Yin Lab at the Wyss Institute, you will play a vital role in advancing our DNA imaging projects. We have developed an innovative pipeline that utilizes DNA barcoding for rapid, high-throughput sequential imaging across various tissue modalities. Reporting to the project leads, you will be an essential part of our research team, contributing to key studies involving the development of DNA-barcoded molecular probes and biomarker detections at the sub-cellular level. This role will also involve closely collaborating on the continuous improvement of our high-throughput biomolecular imaging techniques. [003494SR]

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• Research Assistant III – Brain Targeting Program
  Research and Technology Development

  We are looking for a Research Assistant III to join the Brain Targeting Program (BTP) team and support antibody brain shuttle compound screening and validation in vivo and in vitro. The mission of the Wyss BTP is to develop a robust modular brain delivery platform that is able to deliver large-molecule therapeutics for diverse brain diseases. We aim to help expand the pipeline of CNS drugs by making our platform broadly available to companies, academics and non-profit organizations. The ideal candidate has strong rodent handling experience, including intravenous injection (IV), cardiac perfusion, and brain and peripheral tissue harvesting, is detail orientated and excited for translational research, and thrives in a highly collaborative, fast paced research environment. [003447SR]

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• Research Assistant III – Cell Culture and Blood Clotting-On-Chip
  Research and Technology Development

  We are currently seeking a Research Assistant III to significantly contribute to a research program funded by the Wellcome Leap, “The missed vital sign”, involving the use of human Organ Chips to advance knowledge and development of therapeutics for heavy menstrual bleeding (HMB). We will be developing a human Organ Chip model of HMB and use it to identify causal factors, as well as discover new non-hormonal HMB therapeutics using multi-omics analysis in combination with an artificial intelligence (AI)-enabled computational approach. As part of the Bioinspired Therapeutics & Diagnostics platform and reporting to the Senior Scientist, you will carry out various cell-based assays and manage primary cell cultures, including, but not limited to, primary epithelial and endothelial cell cultures and on chip cultures. Furthermore, you will execute studies on blood perfusion in these human organ chip models of HMB and analyze differences between them and healthy models. You will be expected to learn new skills, and troubleshoot any technical issues that arise, and contribute intellectually to the project. [003424SR]

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• Research Assistant III- Technology Development
  Research and Technology Development

  We are looking for a Research Assistant III to join our work developing novel technologies for biomarker discovery and diagnostics. You will work with a multidisciplinary team on developing novel technologies for investigating pathological states from human biofluids. You will lead development of novel methods that will be used across different diseases. Although you will work within a team and receive significant experimental and computational training, you will also have significant opportunities for scientific independence, and previous RAs working with us have contributed to multiple publications and presented their work at international conferences. [002742SR]

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