Department: Research and Technology Development

Jobs 6

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• Research Assistant III- Diagnostics Accelerator
  Research and Technology Development

  We are looking for a Research Assistant III to join our Diagnostics Accelerator initiative. You will work with a multidisciplinary team on developing multi-omic technologies for investigating pathological states from human biofluids. You will contribute to the development of novel methods that will be used across different diseases to develop new types of liquid biopsy tests. Although you will work within a team and receive significant experimental and computational training, you will also have significant opportunities for scientific independence, and previous RAs working with us have contributed to multiple publications and presented their work at international conferences [67399BR]

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• Principal Engineer- Diagnostics
  Research and Technology Development

  You will have the privilege of contributing to the development of a comprehensive effort focusing on Diagnostics for Human and Planet Health. Reporting to the to the Senior Director of Business Development-Commercialization, you will collaborate with other Wyss leaders, external partners and internal teams to bring the most promising diagnostic technologies into the market. Leading multiple projects, you will focus on developing analytical assays, sensors and diagnostic devices that improve the health and wellbeing of patients and the planet. As a member of the Advanced Technology Team, you will be exposed to many different technology platforms and evaluate them toward their potential to drive scientific understanding, decision-making, and solutions in healthcare and environment, with the unique opportunity to fuel your passion by leading these efforts over time at the Institute or by co-founding a Wyss start-up. [67301BR]

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• Scientist I- Computational Biology
  Research and Technology Development

  Reporting to the Scientist II, you will support computational discovery efforts for an exciting new scientific program focused on elucidating how spaceflight affects human health and blood cell development using human Organ Chips. You will use existing technologies and develop new approaches in the areas of multi-omics analyses as well as statistical and machine learning models. In collaboration with computational and experimental teams within the Wyss and external partners, you will develop hypotheses, interpret data, and advance project goals related to understanding spaceflight-induced changes to human biology. As a member of the Advanced Technology Team (ATT), you will be exposed to many different technologies ranging from therapeutics and diagnostics to synthetic biology and materials science to identify ambitious solutions to problems of global importance and turn these solutions into new products. [67251BR]

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• Research Assistant III – Immune Organs-on-Chip
  Research and Technology Development

  We are looking for a research assistant to join the Intestine and Immune Organs on Chip team in Dr. Don Ingber’s laboratory. We are using immune organs-on-chip to study vaccines, solid tumors, and Lyme Disease. We are using Intestine Organ on Chip to study and model the intestinal tract and microbiome and its influences on diseases, such as malnutrition- associated with environmental enteric dysfunction (EED), inflammatory bowel disease (IBD), and radiationinduced injury, as well as therapeutic responses. With our work, we hope to understand what makes a vaccine effective, create an implantable therapy for cancer, as well as incubate a startup that will design novel Lyme Disease therapeutics. Furthermore, the organ-chip model of intestinal injuries will help us to understand the molecular, genetic and nutritional bases of the disease and the testing of candidate therapeutics for it.

  Reporting to the Principal Scientist leading the team, you will support these studies with the potential to become the go-to person for specific aspects of these research projects. You will learn cutting-edge human immunology and organ-on-chip techniques and may also be exposed to gene editing technology. The ideal candidate is comfortable learning and doing different types of tasks within the same week, has had diverse research experiences, and works well within a team [67136BR]

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• Scientist I – Brain Targeting Program
  Research and Technology Development

  The Wyss Institute’s Brain Targeting Program (BTP), co-led by James Gorman, M.D., Ph.D. and Donald Ingber, M.D., Ph.D., is developing brain delivery technologies that enable development of safer and more effective brain-targeted therapeutics for diverse brain diseases. Our brain delivery platform enables these therapeutic advances by dramatically improving transport of drugs across the blood-brain barrier (BBB) into the brain. We are looking for a talented Scientist to support the development of our brain shuttle-mediated oligonucleotide platform, and to optimize our shuttles for oligonucleotide payloads in neurodegenerative diseases. Reporting to the Principal Scientist, you will work closely with our team using both in vitro cellular systems and in vivo humanized mouse models to optimize oligonucleotide delivery, along with other therapeutic applications of our shuttles. [67208BR]

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