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  • Research Assistant II – Cell Culture and Organs-on-Chip
    Research and Technology Development

    We are currently seeking a Research Assistant to significantly contribute to a research program using Organ on Chip technology to understand the immune cells response in variety of disease settings. Reporting to the Scientist II, in this role you will help isolate immune cells from human donor blood, culture immune cells, carry-out various cell-based assays including, but not limited to; flow cytometry, immunocytochemistry, ELISA, PCR. You will be expected to learn new skills, and troubleshoot any technical issues that arise, and contribute intellectually to the project. [65828BR]

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  • Senior Scientist I
    Research and Technology Development

    Reporting to the Principal Scientist, you will drive the discovery and development of synthetic biology within our growing sustainability initiative. You will work at the intersection of molecular biology, genetics and process engineering to design, construct and optimize synthetic biology systems for applications such as waste remediation, sustainable agriculture and biomanufacturing. As a member of the Advanced Technology team, you will be exposed to many different technologies in areas ranging from therapeutics and diagnostics to synthetic biology and material science, with the goal of identifying new product solutions and the unique potential opportunity to follow your passion either at the Institute or as a future co-founder of a Wyss start-up. [65864BR]

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  • Scientist II- Brain Targeting Program
    Research and Technology Development

    The Wyss Institute’s Brain Targeting Program (BTP), co-led by James Gorman, M.D., Ph.D. and Donald Ingber, M.D., Ph.D., is developing brain delivery technologies that enable development of safer and more effective brain-targeted therapeutics for diverse brain diseases. Our brain delivery platform enables these therapeutic advances by dramatically improving transport of drugs across the blood-brain barrier (BBB) into the brain. We are looking for a talented Scientist to support the discovery and validation of our antibody brain shuttles and to lead the development of our brain shuttle-mediated oligonucleotide platform. Reporting to the Principal Scientist, you will work closely with our team using both in vitro cellular systems and in vivo humanized mouse models to optimize oligonucleotide delivery. [65751BR]

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  • Research Assistant III – Immune Organs-on-Chip
    Research and Technology Development

    We are looking for a research assistant to join the Intestine and Immune Organs on Chip team in Dr. Don Ingber’s laboratory. We are using immune organs-on-chip to study vaccines, solid tumors, and Lyme Disease. We are using Intestine Organ on Chip to study and model the intestinal tract and microbiome and its influences on diseases, such as malnutrition-associated with environmental enteric dysfunction (EED), inflammatory bowel disease (IBD), and radiation-induced injury, as well as therapeutic responses. With our work, we hope to understand what makes a vaccine effective, create an implantable therapy for pancreatic cancer, as well as incubate a startup that will design novel Lyme Disease therapeutics. Furthermore, the organ-chip model of intestinal injuries will help us to understand the molecular, genetic and nutritional bases of the disease and the testing of candidate therapeutics for it.

    Reporting to the Principal Scientist leading the team, you will support these studies with the potential to become the go-to person for specific aspects of these research projects. You will learn cutting-edge human immunology and organ-on-chip techniques and may also be exposed to gene editing technology. The ideal candidate is comfortable learning and doing different types of tasks within the same week, has had diverse research experiences, and works well within a team. [65468BR]

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  • Scientist II – Countermeasure Discovery
    Research and Technology Development

    Reporting to the Senior Scientist II, you will contribute to the discovery effort that combines genetic and small molecule screening with human Organ Chips. As a member of the Advanced Technology team, you will be exposed to many different technologies in areas ranging from therapeutics and diagnostics to synthetic biology and material science, with the goal of identifying new product solutions and the unique potential opportunity to follow your passion either at the Institute or as a future co-founder of a Wyss start-up. [65615BR]

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  • Research Assistant III – RNA Technologies
    Research and Technology Development

    We are looking for a Research Assistant III to join our Diagnostics Accelerator initiative. You will work with a multidisciplinary team on developing RNA-based technologies for investigating pathological states from human biofluids. You will lead development of novel Next Generation Sequencing (NGS) experimental and computational methods that will be used across different diseases. Although you will work within a team and receive significant experimental and computational training, you will also have significant opportunities for scientific independence, and previous RAs working with us have contributed to multiple publications and presented their work at international conferences. [65463BR]

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  • Research Assistant IV – Immunology and Organs-on-Chip
    Research and Technology Development

    We are looking for an enthusiastic and talented individual with previous experience in immunology to join the Bioinspired Therapeutics & Diagnostics platform as a senior and independent Research Assistant. You will significantly contribute to research programs on infectious disease vaccines, post-infection chronic illness and cancer immunology funded by the Gates Foundation, BARDA, ARPA-H and Northpond Ventures. You will work with primary immune cells derived from human blood, tonsils or other tissues, and be responsible for independently planning and executing scientific research involving microfluidic Organ on Chip primary cell culture as well as attenuated laboratory poliovirus strains or other biosafety level 2 pathogens. You will also develop and validate various in-vitro cell based assays. You will be expected to work independently with minimal guidance from academic staff to design experiments, learn new skills, troubleshoot, and to contribute intellectually to the project. [65462BR]

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  • Research Assistant II – Animal Care
    Research and Technology Development

    We are looking for a motivated Research Assistant II to contribute to a multidisciplinary portfolio of research projects involving procedures of health monitoring, injections, blood sampling, survival surgery, post-operative care, and behavioral studies relating to projects on the Synthetic Biology Platform.

    Reporting to the Director of Veterinary Services in coordination with Principal Scientist on the Synthetic Biology Platform at the Wyss Institute, you will be responsible for overseeing study animals, daily rounds, and observations to check animal health status; adherence to protocols and techniques at the animal facility; and performing and documenting experimental observations in rodent species. [65426BR]

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  • Research Assistant II Non-Lab
    Research and Technology Development

    We are looking for a highly motivated clinical research coordinator to support the clinical studies at the Wyss Institute and across our collaborating institutions. Reporting to the Director of Clinical Research, you will be responsible for coordinating clinical studies and trials. [65367BR]

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