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RAPID testing for food contaminants
Contamination of food by microorganisms such as certain bacteria, viruses and fungi is a constant concern, with even miniscule amounts of certain species posing a risk for foods to become unsafe and spoiled during storage. Current safety and quality tests are often not sensitive enough to detect rare species, and because they first require the...
Peptide-based drug delivery to target the brain
The blood-brain-barrier (BBB) is a protective membrane that shields the brain from pathogens, toxins and large water-soluble molecules. Blood vessels throughout the body are lined by endothelial cells that allow some materials to flow from the blood stream into the surrounding tissues. In the brain however, the endothelial cells are more tightly coupled to prevent...
Pathogen Capture Technology for Infectious Disease Therapeutics and Diagnostics
Microbial infection is the cause of life-threatening cases of sepsis, meningitis and multiple other diseases that are major causes of death world-wide. Equally prevalent are pathogenic contaminants in our environment, food, and manufacturing processes. In each case, the presence of dangerous microbes must be confirmed, and when they are found, they need to be removed,...
Human Organs-on-Chips
Clinical studies take years to complete and testing a single compound can cost more than $2 billion. Meanwhile, innumerable animal lives are lost, and the process often fails to predict human responses because traditional animal models often do not accurately mimic human pathophysiology. For these reasons, there is a broad need for alternative ways to...
Microfluidic encapsulation for subcutaneous delivery of viscous drugs
Because of their large molecular sizes and properties, biologic drugs, be it in the form of monoclonal antibodies that target disease-associated molecules or active proteins and enzymes that may correct deficiencies in the human body, have proven difficult to deploy in many cases. Their therapeutic effects on target cells and tissues often require high and...
Tethered Liquid Perfluorocarbon (TLP), a non-stick coating for medical devices
Every device implanted in the body or in contact with flowing blood faces two critical challenges that can threaten the life of the patient it is meant to help: blood clotting and bacterial infection. To confront this challenge, Wyss Institute researchers created a super-repellent, Thin Layer Perfluorocarbon (TLP) coating specifically designed to prevent clot formation...

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