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Technologies 2

• Brain Targeting Program: Shuttles for Brain Delivery of Therapeutics and Diagnostics
  In its Brain Targeting Program, a Wyss team led by Founding Director Donald Ingber, M.D., Ph.D. and Staff Program Lead James Gorman, M.D., Ph.D. is developing improved approaches to target drugs and diagnostics to the brain. Leveraging the human blood-brain barrier (BBB) Chip technology developed by Ingber’s team, combined with advanced antibody R&D capabilities, the...
• Engineered Brain Organoids
  The ability to derive and manipulate pluripotent stem cells has opened up new avenues for modeling biological systems in both healthy and diseased conditions. In order to more fully recapitulate the tissue microenvironment with its cell-cell, cell-extracellular matrix, and cell-niche interactions, it is essential to transition stem-cell culturing from monolayers to 3D structures. Self-organization of...

Collaborations 1

• Brain Targeting Program
  Pre-competitive multi-partner industry collaboration that aims to identify novel transport targets and shuttle compounds to enable more effective delivery of drugs to the brain.

News 6

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• Translation News
  
  Harvard’s Wyss Institute initiates industry partnership to facilitate brain-targeted drug delivery
  June 10, 2021
• Press Release
  
  Enhanced human Blood-Brain Barrier Chip performs in vivo-like drug and antibody transport
  June 13, 2019
• Awards
  
  David Walt and George Church receive grant from Chan Zuckerberg Initiative to enable better diagnosis and monitoring of Parkinson’s disease
  December 5, 2018

Multimedia 1

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  Video/Animation
  Wyss Institute Brain Targeting Program
  This animation explains how Wyss Institute researchers and their industry partners aim to identify novel transport targets and shuttle compounds to enable more effective delivery of drugs to the brain. Credit: Wyss Institute at Harvard University.