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Technologies 1

• MAGE: Multiplex Automated Genomic Engineering
  Developed at the Wyss Institute, the multiplex automated genome engineering (MAGE) technology harnesses the natural principles of evolution to do all the heavy lifting of genome design and automates these steps to dramatically shorten the time scale required to produce microbes with specialized functionalities for manufacturing, sensing and therapeutic applications. Genome engineering has a wide...

News 9

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• Research Spotlights
  
  DNA: From blueprint to blank slate
  April 23, 2021
• Press Release
  
  Enzymatic DNA synthesis sees the light
  October 19, 2020
• Research Spotlights
  
  Editing genomes not dozens but thousands of times in one go
  May 12, 2020

Multimedia 2

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  Video/Animation
  AAV Capsid Engineering
  Wyss researchers have created a high-throughput platform to generate an Adeno-associated virus 2 (AAV2) library containing 200,000 variants, each carrying a distinct mutation in the virus capsid protein. Their analysis identified capsid changes that enhanced “homing” potential to specific organs in mice and virus viability, as well as a new protein hidden in the capsid-encoding...

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  Video/Animation
  CRISPR-Cas: Molecular Recording
  In this video, Wyss Institute and Harvard Medical School researchers George Church and Seth Shipman explain how they engineered a new CRISPR system-based technology that enables the chronological recording of digital information, like that representing still and moving images, in living bacteria. Credit: Wyss Institute at Harvard University