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Technologies 4

• Metabolically Labeled CAR-T Cells Against Cancer
  Through a simple and effective metabolic labeling approach, patient-derived T cells engineered to carry immune-enhancing cytokines on their surfaces could help expand adoptive T cell therapies to treatment of solid tumors and improve blood cancer therapies.
• Plastivores: Plastic-Degrading Super-Microbes and Enzymes
  The Plastic Degradation project identifies microbes from natural sources that have a low-level ability to degrade multiple types of plastic. In the laboratory, with the help of synthetic biology, those microbes then are evolved into much more effective plastic-eating microbes that, in the future, could be globally deployed to decompose plastic waste.
• Circe: Transforming greenhouse gases into valuable products with microbes
  Circe Bioscience is using gas fermentation to produce valuable materials including fats, oils, and fuels from greenhouse gases using engineered microbes.
• Bioplastics
  Humans have produced roughly 8,300 million metric tons of plastic since the 1950s, the vast majority of which has been thrown out as waste. Only about 9% of that plastic waste has been recycled and 12% has been incinerated, leaving 79% of it to accumulate on our land and oceans, harming the environment, the food...

News 21

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• Press Release
  
  DARPA-ABC program supports Wyss Institute-led collaboration toward deeper understanding of anesthesia and safe drugs enabling anesthesia without the need for extensive monitoring
  January 15, 2025
• Press Release
  
  “Suspended animation” drug could aid organ transplantation and survival from traumatic injury
  September 24, 2024
• Translation News
  
  Circe Bioscience licenses technology to decarbonize industry with microbes developed at Wyss Institute at Harvard University
  May 15, 2024

Multimedia 3

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  Video/Animation
  Metabolic T cell Labeling: simple and effective enhancement of therapeutic T cells with immune-stimulating cytokines
  This animation shows how the surface of patient-derived T cells is metabolically labeled with azido-sugar molecules that then can be used to attach immune-enhancing cytokines with the help of click chemistry. The approach could help expand adoptive T cell therapies to treatment of solid tumors. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Circe: Using Microbes to Make Biodegradable Products
  Current manufacturing methods release harmful greenhouse gases and pollution, and many of the products produced do not biodegrade, damaging our ecosystems even further. What if we could turn greenhouse gases into biodegradable products? Researchers at the Wyss Institute are using synthetic biology to make this a reality. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Light-driven fine chemical production in yeast biohybrids
  Wyss Institute Core Faculty member Neel Joshi explains the concept of yeast biohybrids and how they can be used to harvest energy from light to drive the production of fine chemicals. Credit: Wyss Institute at Harvard University