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Technologies 5

• Plastivores: Plastic-Degrading Super-Microbes and Enzymes
  The Plastic Degradation project identifies microbes from natural sources that have a low-level ability to degrade multiple types of plastic. In the laboratory, with the help of synthetic biology, those microbes then are evolved into much more effective plastic-eating microbes that, in the future, could be globally deployed to decompose plastic waste.
• Metabolically Labeled CAR-T Cells Against Cancer
  Through a simple and effective metabolic labeling approach, patient-derived T cells engineered to carry immune-enhancing cytokines on their surfaces could help expand adoptive T cell therapies to treatment of solid tumors and improve blood cancer therapies.
• Circe: Tailored Fats for Food Applications
  Circe Bioscience spun out of the Wyss Institute in 2023 to commercialize their gas-fermentation-based technology that uses engineered microbes to convert greenhouse gases into fats for use in food products without the use of plants or animals.
• Circe: Transforming Greenhouse Gases into Biodegradable Products
  Circe is a platform technology that uses engineered microbes to produce valuable, biodegradable synthetic polymers from greenhouse gases, minimizing the environmental impact of manufacturing. Potential applications include biodegradable plastics and packaging, energy-efficient agriculture, clean personal care products, and more. Circe is a platform technology that uses engineered microbes to produce valuable, biodegradable synthetic polymers from greenhouse gases, minimizing the environmental impact of manufacturing. Potential applications include biodegradable plastics and packaging, energy-efficient agriculture, clean personal care products, and more.
• Bioplastics
  Humans have produced roughly 8,300 million metric tons of plastic since the 1950s, the vast majority of which has been thrown out as waste. Only about 9% of that plastic waste has been recycled and 12% has been incinerated, leaving 79% of it to accumulate on our land and oceans, harming the environment, the food...

News 17

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• Community
  
  Solving tough problems together
  July 12, 2023
• Press Release
  
  Direct control of dendritic cells for tracking and immune modulation
  May 18, 2020
• Press Release
  
  Discovery of performance-enhancing bacteria in the human microbiome
  June 24, 2019

Multimedia 3

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  Video/Animation
  Metabolic T cell Labeling: simple and effective enhancement of therapeutic T cells with immune-stimulating cytokines
  This animation shows how the surface of patient-derived T cells is metabolically labeled with azido-sugar molecules that then can be used to attach immune-enhancing cytokines with the help of click chemistry. The approach could help expand adoptive T cell therapies to treatment of solid tumors. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Circe: Using Microbes to Make Biodegradable Products
  Current manufacturing methods release harmful greenhouse gases and pollution, and many of the products produced do not biodegrade, damaging our ecosystems even further. What if we could turn greenhouse gases into biodegradable products? Researchers at the Wyss Institute are using synthetic biology to make this a reality. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Light-driven fine chemical production in yeast biohybrids
  Wyss Institute Core Faculty member Neel Joshi explains the concept of yeast biohybrids and how they can be used to harvest energy from light to drive the production of fine chemicals. Credit: Wyss Institute at Harvard University