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Technologies 3

• Single-Cell Encapsulation for Improved Cell Therapies
  Mesenchymal stromal cells (MSCs) are valued for their ability to secrete compounds that modulate the body’s immune system, making them an attractive solution for existing problems with cell therapies including host-vs-graft disease and organ transplant rejections. However, MSCs are rapidly cleared from the body and can come under fire from the immune system. Efforts to...
• Brain-Targeting Shuttles for Drug Delivery and Diagnostics
  In its Brain Targeting Program, a Wyss team led by Founding Director Donald Ingber, M.D., Ph.D. and Staff Program Lead James Gorman, M.D., Ph.D. is developing improved approaches to target drugs and diagnostics to the brain. Leveraging the human blood-brain barrier (BBB) Chip technology developed by Ingber’s team, combined with advanced antibody R&D capabilities, the...
• Engineered Brain Organoids
  The ability to derive and manipulate pluripotent stem cells has opened up new avenues for modeling biological systems in both healthy and diseased conditions. In order to more fully recapitulate the tissue microenvironment with its cell-cell, cell-extracellular matrix, and cell-niche interactions, it is essential to transition stem-cell culturing from monolayers to 3D structures. Self-organization of...

News 17

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• Press Release
  
  A swifter way towards 3D-printed organs
  September 6, 2019
• Press Release
  
  Helping transplanted stem cells stick around and do their jobs
  July 15, 2019
• Press Release
  
  Enhanced human Blood-Brain Barrier Chip performs in vivo-like drug and antibody transport
  June 13, 2019

Events 1

• May 2, 2017,
  4:00pm - 5:00pm
  Wyss Event
  
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  Engineering Stem Cell Therapies for Heart Repair
  No therapy currently available can reduce the size of an established scar on the heart. Cell therapy aims to alter this fixed trajectory for Myocardial Infarction (MI) survivors: to intervene adverse heart remodeling, to reduce scar size, and to actually regenerate viable myocardial tissue. The last one and half decades witnessed the booming of stem... Free and open to public

Multimedia 5

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  Video/Animation
  A Swifter Way Towards 3D-printed Organs
  20 people die waiting for an organ transplant every day in the US, but lab-grown organs so far lack the cellular density and functions required to make them viable replacements. The new SWIFT method from the Wyss Institute and Harvard SEAS solves those problems by 3D printing vascular channel networks directly into living tissue constructs,...

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  Video/Animation
  New Wyss Institute Initiative – 3D Organ Engineering
  Wyss Institute Core Faculty members Christopher Chen and Jennifer Lewis describe the Wyss Institute’s new initiative focused on organ engineering, which leverages our expertise in biomaterials, tissue engineering, three dimensional biofabrication, and stem cell development.

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  Video/Animation
  Efficient Recovery of Stem Cell Sheets
  See in this video how an intact sheet of mesenchymal stem cells, stained with a violet dye, can be lifted off the infused polymer substrate in the culture dish using a filter paper and transferred to a new surface. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Printing Vascular Tissue
  Printing vessel vasculature is essential for sustaining functional living tissues. Until now, bioengineers have had difficulty building thick tissues, lacking a method to embed vascular networks. A 3D bioprinting method invented at the Wyss Institute and Harvard SEAS embeds a grid of vasculature into thick tissue laden with human stem cells and connective matrix. Printed...

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  Video/Animation
  Shrinking Gel
  When the temperature rises to just below body temperature, this biocompatible gel shrinks dramatically within minutes, bringing tooth-precursor cells (green) closer together. Credit: Basma Hashmi