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228 Results for 'Therapeutics'
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Technologies 24
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Injectable Alginate Hydrogels for Medical Applications
One of the biggest challenges in medicine is getting a drug to the right part of the body at the right time. Even when the target site in the body is known, like a pain-causing injury or a cancerous tumor, most drugs are given as oral pills or intravenous infusions, which limits their effectiveness. In... -
Liquid-Infused Tympanostomy Tubes
Acute middle ear infections affect more than 700 million people each year, with children often experiencing the most recurrent and severe symptoms due to their underdeveloped physiology. By the age of three, 25-40 % of children have had at least three episodes of acute middle ear infection, which is commonly accompanied by excess fluids accumulating... -
CogniXense – A high-throughput cognitive screen for modeling disorders on-the-fly
There are more than 6,000 known single-gene disorders, in which a disruption to one gene out of the 20,000 in the human genome is enough to cause significant health effects. In order to study these disorders and develop treatments, a given genetic mutation must first be induced in a large number of animal models (usually... -
Synthetic AAV virus capsids for advanced gene therapy
The protein shell (capsid) of Adeno-associated viruses (AAV) are presently the most promising delivery vehicles for various in vivo gene therapies. AAVs are non-pathogenic and, through past engineering efforts, have become safe due to their inability to integrate into and damage the genome of target cells. Rather, the delivered DNA containing a therapeutic gene of... -
Customizable scaffolds for faster, higher-quality T cell production
Immunotherapy, or tweaking the body’s own immune system to treat disease, is attracting significant attention in the medical field for its potential to offer long-lasting cures with fewer side effects than chemotherapy or other drugs. One type of immunotherapy involves isolating T cells (a type of white blood cell) from a patient’s body, sometimes modifying... -
Toehold switches as versatile tools for synthetic biology applications
The burgeoning field of synthetic biology is designing artificial gene circuits that recognize molecules in their environment and respond by regulating genes with desired activities. In the future, such capabilities could allow the engineering of cells as diagnostic or therapeutic devices, factories for the production of clinically or industrially coveted molecules, and as specialized devices...
News 161
Multimedia 43
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Video/AnimationOrigami OrgansA multidisciplinary team of scientists, engineers, and architectural designers are developing Origami Organs that could function like artificial kidneys. Credit: Wyss Institute at Harvard University -
Video/AnimationLe Lab Presents: Designing Future Therapeutics with Samir MitragotriWyss Core Faculty member Samir Mitragotri, Ph.D. presented a talk at Le Laboratoire Cambridge on February 13th, 2019, titled Designing Future Therapeutics. Effective delivery of therapeutics is a major problem in today’s healthcare. At a fundamental level, the challenge of therapeutic delivery reflects the fact that the drug distribution in the body is limited by body’s... -
Video/AnimationScience Nation: Engineering soft robots for paradigm shift in rehabilitationThis video was produced by the National Science Foundation: Tim Gatautis suffered a spinal cord injury in a swimming accident nearly a decade ago and he’s had to use a wheelchair ever since. Gatautis would like to be able to do more for himself, which brings him to the Wyss Institute and the Biodesign Lab... -
Video/AnimationToehold Exchange ProbesThis animation explains how toehold probes consisting of a “probe strand” and a “protector strand” are assembled and how they leverage thermodynamic principles to allow the specific detection of a correct target sequence, or to prevent them from detecting a spurious target sequence that can differ from the correct target sequence by only a single... -
Audio/PodcastDisruptive: Cancer Vaccine and Immuno-MaterialsImmunotherapy – treatment that uses the body’s own immune system to help fight disease – has groundbreaking and life-saving implications. In an effort to make immunotherapy more effective, Wyss Institute researchers are developing new immuno-materials, which help modulate immune cells to treat or diagnose disease. In this episode of Disruptive, Dave Mooney, Wyss Core Faculty... -
Video/AnimationSoft Exosuit for Post-stroke Gait Re-trainingThis video explains how exosuit technology, developed at the Wyss Institute for Biologically Inspired Engineering, applied to ankle movements helps patients post-stroke regain a more normal gait. Credit: Wyss Institute at Harvard University