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Technologies 1

• DNA Nanostructures for Drug Delivery
  Researchers at the Wyss Institute have developed two methods for building arbitrarily shaped nanostructures using DNA, with a focus on translating the technology towards nanofabrication and drug delivery applications. One proprietary nanofabrication technique, called “DNA-brick self-assembly,” uses short, synthetic strands of DNA that work like interlocking Lego® bricks. It capitalizes on the ability to program...

News 12

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• Video/​Animation Molecular Robotics at the Wyss Institute
  January 17, 2018
• Community William Shih: Lego-Style Construction of Future Therapeutics From DNA
  February 15, 2017
• Community Innovative future of therapeutics highlighted at the first Wyss Annual Diabetes Symposium
  March 27, 2015

Events 1

• Feb 15, 2017, 6:30pm - 7:30pm Lecture
  
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  Art Science @ Le Lab, Lecture Series: Lego-Style Construction of Future Therapeutics From DNA
  Core Faculty member William Shih will discuss how custom molecular shapes can be designed using DNA building blocks and how these minuscule devices could have a profound impact on fields ranging from molecular biophysics to therapeutics to nano-optics for decades to come. Register using the link below and click here to view the full Spring... Free and open to public

Multimedia 6

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  Audio/Podcast
  William Shih: Lego-Style Construction of Future Therapeutics From DNA
  Listen to Wyss Core Faculty member William Shih’s lecture on how custom molecular shapes can be designed using DNA building blocks and how these minuscule devices could have a profound impact on fields ranging from molecular biophysics to therapeutics to nano-optics for decades to come. Shih’s lecture is part of the ArtScience lecture series at...

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  Audio/Podcast
  Disruptive: Molecular Robotics
  How can DNA be programmed to build novel structures, devices, and robots? We have taken our understanding of DNA to another level, beginning to take advantage of some of DNA’s properties that have served nature so well, but in ways nature itself may have never pursued. Humans can now use DNA as a medium for...

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  Video/Animation
  Virus-inspired DNA Nanodevices
  Wyss Institute Core Faculty member William Shih and Technology Development Fellow Steven Perrault explain why DNA nanodevices need protection inside the body, and how a viral-inspired strategy helps protect them. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Building 3D Structures with DNA Bricks
  The nanofabrication technique, called ‘DNA-brick self-assembly,’ uses short, synthetic strands of DNA that work like interlocking Lego bricks. It capitalizes on the ability to program DNA to form into predesigned shapes thanks to the underlying ‘recipe’ of DNA base pairs. This animation accurately shows how the DNA strands self assemble to build a structure.DNA Nanostructures...

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  Video/Animation
  DNA Bricks: Molecular Animation
  The nanofabrication technique, called ‘DNA-brick self-assembly,’ uses short, synthetic strands of DNA that work like interlocking Lego bricks. It capitalizes on the ability to program DNA to form into predesigned shapes thanks to the underlying “recipe” of DNA base pairs. Animation created by Digizyme for the Wyss Institute. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Making Structures with DNA “Building Blocks”
  Researchers at the Wyss Institute have developed a method for building complex nanostructures out of short synthetic strands of DNA. Called single-stranded tiles (SSTs), these interlocking DNA “building blocks,” akin to Legos, can be programmed to assemble themselves into precisely designed shapes, such as letters and emoticons. Credit: Wyss Institute at Harvard University