Wyss Core Faculty member Samir Mitragotri, Ph.D. presented a talk at Le Laboratoire Cambridge on February 13th, 2019, titled Designing Future Therapeutics. Effective delivery of therapeutics is a major problem in today’s healthcare. At a fundamental level, the challenge of therapeutic delivery reflects the fact that the drug distribution in the body is limited by body’s natural metabolic processes and transport barriers. These biological barriers, while serving an important purpose of regulating body’s metabolic functions, limit the drug dose that ultimately reaches the target site. Accordingly, many drugs fail to reach their full therapeutic potential. We are developing a fundamental understanding of body’s key biological barriers and using this understanding to develop novel means to negotiate these barriers to deliver drugs. Samir Mitragotri, also the Hiller Professor of Bioengineering and Hansjorg Wyss Professor of Biologically Inspired Engineering at the Harvard John A. Paulson School of Engineering and Applied Sciences, presents an overview of the lessons learned from his exploration of these biological barriers.