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DNA Nanoswitches: “Lab-on-a-Molecule” Drug Discovery
The Lab-on-a-Molecule platform leverages the Wyss Institute’s DNA nanotechnology technology for the high-throughput, low-cost screening of a wide range of chemical and biologic compounds to enable the discovery of first-in-class therapeutics for various conditions.
DoriVac: Boosting Antigen-specific Immune Responses with DNA Origami-Based Vaccines
Personalized cancer and infectious disease vaccine platform harnessing DNA nanotechnology to control the co-delivery and co-presentation of tumor antigen and adjuvant ligands to immune cells with nanoscale precision. This approach has potential to trigger enhanced immune responses against tumors and infectious pathogens.
Crisscross Nanoseed Detection: Nanotechnology-Powered Infectious Disease Diagnostics
This nanotech-based diagnostic platform uses a unique nucleation mechanism that assembles a DNA "nanoseed" in the presence of a pathogen-derived biomarker that then is amplified within 15 minutes to create a signal for easy detection. It is highly robust, and cost-effective, and can be adapted to detect a variety of biomarkers.
DNA Nanotechnology Tools: From Design to Applications
A suite of diverse, multifunctional DNA nanotechnological tools with unique capabilities and potential for a broad range of clinical and biomedical research areas. Our DNA nanotechnology devices were engineered to overcome specific bottlenecks in the development of new therapies and diagnostics, and to help further our understanding of molecular structures.
DNA Nanostructures for Drug Delivery
Researchers at the Wyss Institute have developed two methods for building arbitrarily shaped nanostructures using DNA, with a focus on translating the technology towards nanofabrication and drug delivery applications. One proprietary nanofabrication technique, called “DNA-brick self-assembly,” uses short, synthetic strands of DNA that work like interlocking Lego® bricks. It capitalizes on the ability to program...
Multiplexed Molecular Force Spectroscopy
Programmable DNA nanoswitches, invented at the Wyss Institute, can now be used in combination with a benchtop Centrifuge Force Microscope (CFM) as a highly reliable tool to observe thousands of individual molecules and their responses to mechanical forces in parallel. By analyzing the responses of single molecules under conditions where they experience such forces, it is possible...
Inexpensive Super-Resolution Microscopy
Wyss Institute scientists have developed a highly versatile and inexpensive microscopic imaging platform designed to visualize objects with molecular-scale resolution and unprecedented complexity. The DNA-powered imaging technology can reveal the inner workings of cells at the single molecule level, using conventional microscopes found in most laboratories. Key to the Wyss Institute’s DNA-driven imaging super resolution...