Application Area: Brain Disease

Technologies 1

• Engineered Brain Organoids
  The ability to derive and manipulate pluripotent stem cells has opened up new avenues for modeling biological systems in both healthy and diseased conditions. In order to more fully recapitulate the tissue microenvironment with its cell-cell, cell-extracellular matrix, and cell-niche interactions, it is essential to transition stem-cell culturing from monolayers to 3D structures. Self-organization of...

Collaborations 4

• Brain Targeted Therapeutic Collaboration
  Combine our shuttles with your drugs to create new brain targeted therapeutics for patients.
• Brain Shuttle Research Sponsorship & Licensing
  Enabling brain-targeted drug development through non-exclusive licensing and pre-competitive research sponsorship.
• Bridging the Funding Gap for Brain Therapeutics
  A unique opportunity to help develop a new generation of brain targeted drugs
• Wyss Brain Targeting Program
  Advancing brain delivery approaches that enable more safe and effective brain-targeted therapeutics.

News 21

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• Community
  
  Gina Wang on having the NERVE to detect ALS
  November 21, 2025
• Translation News
  
  Crossing the barrier: Wyss Brain Targeting Program is delivering on its promise
  October 22, 2025
• Awards
  
  The Wyss Institute’s 2025-2026 Validation Projects
  August 14, 2025

Multimedia 7

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  Audio/Podcast
  Brain Shuttles: A New Path Into the Brain with James Gorman of the Wyss Institute
  The host of Business Trip, Matias Serebrinsky, interviews Wyss Senior Director of Translational R&D James (Jim) Gorman, M.D., Ph.D. Jim is a Principal Investigator of the Wyss Institute Brain Targeting Program (BTP). He leads a team developing new approaches to transport drugs through the blood-brain barrier (BBB) into the central nervous system. In this episode,...

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  Video/Animation
  20-ish Questions with Ellen Roche
  20-ish Questions shows a different side of Wyss Institute faculty, touching on aspects of their personal life, hobbies, interests, as well as their research. This round follows Ellen Roche, an Associate Faculty member of the Wyss Institute as well as the Latham Family Career Development Professor at the Department of Mechanical Engineering and the Institute...

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  Video/Animation
  How can we better treat brain diseases?
  The Brain Targeting Program at the Wyss Institute is a pre-competitive, multi-partner industry collaboration that aims to identify novel transport targets and shuttle compounds to enable more effective delivery of drugs to the brain. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Reimagining Neurodegenerative Disease Treatment for Her Grandfather: Mariana Garcia-Corral
  Mariana Garcia-Corral is a Research Assistant studying brain organoids to help with the treatment of bipolar disorder. In this video, she shares a poignant personal story about her grandfather suffering from Lewy body dementia and how she would Reimagine a World with better neurodegenerative disease treatment. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Reimagine the World: Volume 1
  Four Wyss Institute scientists, Mariana Garcia-Corral, Pawan Jolly, Megan Sperry, and Mike Super, share how they would Reimagine the World and the personal stories that fuel their passion for the work they are doing. We’d love to hear how you would Reimagine the World! Please visit the following link to share your ideas: https://wyss.typeform.com/to/o9xM7cG1 Credit:...

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  Video/Animation
  Eliminating brain cancer at its source | Natalie Artzi | TEDxMIT
  Glioblastoma is a lethal, aggressive brain cancer with a dismal median overall survival rate of 15 months, a number that has remained unchanged for decades. Treatment for this devastating disease involves surgical resection followed by chemotherapy and radiation therapy; however, tumor recurrence is inevitable as it is impossible to eliminate all tumor cells with current...