Application Area: Kidney Disease

Technologies 1

• Human Organs-on-Chips
  Organ Chips are microfluidic devices lined with living human cells for drug development, disease modeling, and personalized medicine. Launched in 2014, Wyss startup Emulate, Inc., is leveraging the Wyss Institute’s Organ Chip technology to mimic human organs in vitro, enabling faster, better, and cheaper drug development and insights into human health.

News 19

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• Press Release
  
  Adding immunity to human kidney-on-a-chip advances cancer drug testing
  August 23, 2023
• Translation News
  
  Harvard Wyss Institute’s eRapid multiplexed biosensor technology licensed to StataDX to enable new diagnostics for neurological, cardiovascular, and renal diseases
  June 24, 2022
• Translation News
  
  Harvard University licenses kidney engineering technology to Trestle Biotherapeutics to facilitate new kidney replacement therapies
  February 22, 2022

Multimedia 7

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  Video/Animation
  Interrogator: Human Organ-on-Chips
  This video describes the “Interrogator” instrument that can be programmed to culture up to 10 different Organ Chips and sequentially transfer fluids between their vascular channels to mimic normal human blood flow between the different organs of our body. Its integrated microscope enables the continuous monitoring of the tissues’ integrities in the individual organ chips...

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  Video/Animation
  Origami Organs
  A multidisciplinary team of scientists, engineers, and architectural designers are developing Origami Organs that could function like artificial kidneys. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Kidney Organiods: Flow-Enhanced Vascularization and Maturation In Vitro
  This video explains how the collaborative project created vascularized kidney organoids and how they advance the field of tissue engineering. Credit: Wyss Institute at Harvard University.

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  Video/Animation
  Podocyte Cells: Kidney-on-a-Chip
  This video shows a 3-dimensional rendering of the glomerulus-on-a-chip with human stem cell-derived mature podocytes (in green) grown and differentiated in one channel (shown on top) and that extend their processes through the modeled glomerulus basement membrane towards glomerular vascular cells (in magenta) in the parallel running channel (shown on the bottom). Credit: Wyss Institute...

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  Video/Animation
  Bioprinting: The Kidney’s Proximal Tubules
  In this video, see how the Wyss Institute team has advanced bioprinting to the point of being able to fabricate a functional subunit of a kidney. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Human Organs-On-Chips
  Wyss Institute researchers and a multidisciplinary team of collaborators have engineered microchips that recapitulate the microarchitecture and functions of living human organs, including the lung, intestine, kidney, skin, bone marrow and blood-brain barrier. These microchips, called ‘organs-on-chips’, offer a potential alternative to traditional animal testing. Each individual organ-on-chip is composed of a clear flexible polymer...