Application Area: Sepsis

Technologies 2

• Pathogen Capture Technology for Infectious Disease Therapeutics and Diagnostics
  Microbial infection is the cause of life-threatening cases of sepsis, meningitis and multiple other diseases that are major causes of death world-wide. Equally prevalent are pathogenic contaminants in our environment, food, and manufacturing processes. In each case, the presence of dangerous microbes must be confirmed, and when they are found, they need to be removed,...
• Tethered Liquid Perfluorocarbon (TLP), a non-stick coating for medical devices
  Every device implanted in the body or in contact with flowing blood faces two critical challenges that can threaten the life of the patient it is meant to help: blood clotting and bacterial infection. To confront this challenge, Wyss Institute researchers created a super-repellent, Thin Layer Perfluorocarbon (TLP) coating specifically designed to prevent clot formation...

News 23

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• Research Spotlights Overhauling diagnostics for better patient care
  September 17, 2019
• Translation News Wyss Institute and Miraki Innovation Unveil BOA Biomedical to Reduce Sepsis Deaths
  September 10, 2019
• Press Release A new model for an old killer
  March 8, 2018

Multimedia 6

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  Audio/Podcast
  Disruptive: Confronting Sepsis
  In this episode of Disruptive, Wyss Institute Founding Director Don Ingber and Senior Staff Scientist Mike Super discuss how their team developed a new therapeutic device inspired by the human spleen. This blood-cleansing approach can remove sepsis-causing pathogens from circulating blood without ever needing to know their identity. In animal studies, treatment with this device...

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  Video/Animation
  Pathogen-Extracting Sepsis Therapy
  This video explains how sepsis induced by an overload of blood pathogens can be treated with the Wyss Institute’s improved pathogen-extracting, spleen-mimicking device. Blood is flown through a cartridge filled with hollow fibers that are coated with a genetically engineered blood protein inspired by a naturally-occurring human molecule called Mannose Binding Lectin (MBL). MBL is...

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  Video/Animation
  Antibiotic Efficacy
  In this video, Wyss Institute Core Faculty member James Collins and Michael Lobritz explain how antibiotics can have vastly different effects on pathogenic bacteria and suggest potential implications for improving antibiotic treatments in infected patients. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Bioinspired Blood Repellent Coating
  In this video, Wyss Institute Founding Director Don Ingber, Core Faculty member Joanna Aizenberg, Staff Scientist Dan Leslie and Postdoctoral Fellow Anna Waterhouse explain how a coating they developed using FDA-approved materials could prevent blood clotting in medical devices without the use of blood thinners. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Bioinspired Approach to Sepsis Therapy
  Wyss Institute Founding Director Don Ingber, Senior Staff Scientist Michael Super and Technology Development Fellow Joo Kang explain how they engineered the Mannose-binding lectin (MBL) protein to bind to a wide range of sepsis-causing pathogens and then safely remove the pathogens from the bloodstream using a novel microfluidic spleen-like device. Credit: Wyss Institute at Harvard...

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  Video/Animation
  Introduction to Sepsis Diagnostic
  What if we could diagnose sepsis in just hours, not days? Wyss Institute researchers discuss their approach to a rapid sepsis diagnostic. Credit: Wyss Institute at Harvard University