Application Area: Toxicology

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Audio/Podcast

Next-Gen Toxicology: Inside the Organ Chip Revolution with Donald Ingber
In this episode of ToxChats, hosts Lauren Walker and Sarah Benjamin sit down with the groundbreaking Donald Ingber—visionary scientist, engineer, and Founding Director of the Wyss Institute. Ingber shares how his unique path through medicine, biology, and design converged to spark breakthroughs such as human Organ Chips—systems that are redefining toxicology, drug development, and disease...
Video/Animation

AminoX: Making Better Protein Drugs, Quicker and Cheaper
A synthetic biology and advanced chemistry platform that efficiently incorporates non-standard amino acids by hacking the ubiquitous protein synthesis process. Credit: Wyss Institute at Harvard University
Video/Animation

Kidney Organiods: Flow-Enhanced Vascularization and Maturation In Vitro
This video explains how the collaborative project created vascularized kidney organoids and how they advance the field of tissue engineering. Credit: Wyss Institute at Harvard University.
Video/Animation

This is Your Brain on Chips
How do you study something as complex as the human brain? Take it apart. Wyss researchers have created Organ Chips that mimic the blood-brain barrier and the brain and, by linking them together, discovered how our blood vessels and our neurons influence each other. Credit: Wyss Institute at Harvard University
Video/Animation

3D Printed Heart-on-a-Chip
In this video, learn how Wyss Institute and Harvard SEAS researchers have created a 3D-printed heart-on-a-chip that could lead to new customizable devices for short-term and long-term in vitro testing. Credit: Johan U. Lind (Disease Biophysics Group), Alex D. Valentine and Lori K. Sanders (Lewis Lab)/Harvard University
Video/Animation

Bioprinting: The Kidney’s Proximal Tubules
In this video, see how the Wyss Institute team has advanced bioprinting to the point of being able to fabricate a functional subunit of a kidney. Credit: Wyss Institute at Harvard University
Video/Animation

Human Organs-On-Chips
Wyss Institute researchers and a multidisciplinary team of collaborators have engineered microchips that recapitulate the microarchitecture and functions of living human organs, including the lung, intestine, kidney, skin, bone marrow and blood-brain barrier. These microchips, called ‘organs-on-chips’, offer a potential alternative to traditional animal testing. Each individual organ-on-chip is composed of a clear flexible polymer...
Audio/Podcast

Building Organs, On One Microchip At A Time
Building Organs, On One Microchip At A Time was originally broadcast on NPR on July 29, 2012. This story features Wyss Core Faculty member Don Ingber. Original broadcast story can be found here.
Video/Animation

Introduction to Organs-on-a-Chip
What if we could test drugs without animal models? Wyss Institute researchers and a multidisciplinary team of collaborators have engineered microchips that recapitulate the microarchitecture and functions of living human organs, including the lung, intestine, kidney, skin, bone marrow and blood-brain barrier. These microchips, called ‘organs-on-chips’, offer a potential alternative to traditional animal testing. Each...
Video/Animation

Introduction to Sepsis Diagnostic
What if we could diagnose sepsis in just hours, not days? Wyss Institute researchers discuss their approach to a rapid sepsis diagnostic. Credit: Wyss Institute at Harvard University
Video/Animation

Lung-on-a-Chip
Combining microfabrication techniques with modern tissue engineering, lung-on-a-chip offers a new in vitro approach to drug screening by mimicking the complicated mechanical and biochemical behaviors of a human lung. This extended version of the video includes our findings when we mimicked pulmonary edema on the chip. Credit: Wyss Institute at Harvard University