Discipline: Nanotechnology

Technologies 4

• DNA Nanostructures for Drug Delivery
  Researchers at the Wyss Institute have developed two methods for building arbitrarily shaped nanostructures using DNA, with a focus on translating the technology towards nanofabrication and drug delivery applications. One proprietary nanofabrication technique, called “DNA-brick self-assembly,” uses short, synthetic strands of DNA that work like interlocking Lego® bricks. It capitalizes on the ability to program...
• Mechanically-Activated Drug Targeting Nanotechnology
  The Wyss team has developed a novel drug targeting nanotechnology that is activated locally by mechanical forces, either endogenous high shear stresses in blood created by vascular occlusion or mechanical energy applied locally using low-energy ultrasound radiation. Today, vascular blockage is the leading cause of death and disability in United States and Europe. Current therapies...
• Inexpensive Super-Resolution Microscopy
  Wyss Institute scientists have developed a highly versatile and inexpensive microscopic imaging platform designed to visualize objects with molecular-scale resolution and unprecedented complexity. The DNA-powered imaging technology can reveal the inner workings of cells at the single molecule level, using conventional microscopes found in most laboratories. Key to the Wyss Institute’s DNA-driven imaging super resolution...
• Paper-based synthetic gene networks as a new diagnostic approach
  With the imminent threat of new pandemics and frequent disease outbreaks exemplified by the recent Ebola and Zika epidemics, there is a growing need for low-cost, easily deployable and simple-to-use diagnostic tools. The Wyss Institute has developed paper-based synthetic gene networks as a next generation diagnostic technology for use in global healthcare crises and patient...

News 46

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• Press Release Slippery liquid surfaces confuse mussels to stop them from sticking to underwater structures
  August 17, 2017
• Press Release Extremely colorful, incredibly bright and highly multiplexed
  June 21, 2017
• Research Spotlights Portable nanofiber device offers precise, point-and-shoot capability for fabricating 3D tissue and smart fabrics
  March 1, 2017

Multimedia 3

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  Audio/Podcast
  Disruptive: Molecular Robotics
  How can DNA be programmed to build novel structures, devices, and robots? We have taken our understanding of DNA to another level, beginning to take advantage of some of DNA’s properties that have served nature so well, but in ways nature itself may have never pursued. Humans can now use DNA as a medium for...

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  Video/Animation
  Bioinspired Approach to Sepsis Therapy
  Wyss Institute Founding Director Don Ingber, Senior Staff Scientist Michael Super and Technology Development Fellow Joo Kang explain how they engineered the Mannose-binding lectin (MBL) protein to bind to a wide range of sepsis-causing pathogens and then safely remove the pathogens from the bloodstream using a novel microfluidic spleen-like device. For more information, please visit...

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  Video/Animation
  Fluorescent in situ Sequencing
  In this video, George Church, Ph.D., a Core Faculty member at the Wyss Institute and Professor of Genetics at Harvard Medical School, explains how fluorescent in situ sequencing could lead to new diagnostics that spot the earliest signs of disease, and how it could help reveal how neurons in the brain connect and function. Credit:...