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From Mechanical Forces to Tissue Straining – How Biophysical Cues Can Be Used to Guide Regeneration: Topics in Bioengineering Seminar


Harvard John A. Paulson School of Engineering and Applied Sciences Topics in Bioengineering presents this lecture by Georg Duda, Wyss Institute Associate Faculty Member.

Conceptually, our research aims at understanding endogenous cascades of tissue formation, cytokine signaling and cellular self-organization especially in bone. Mechanical straining and adaptation due to mechanical cues plays a central role in all these tissues. The aim of our work is to understand the mechano-biological cues of regeneration and adaptation an dhow they can be employed to enable healing even in tissues with impaired regenerative capacity such as muscle, cartilage or tendon. All approaches are motivated by clinical challenges, are based on in vivo patient measurements, employ basic research principles and aim at being translated into daily clinical routine. Examples of translation include innovative concepts for joint replacement procedures, angle stable fixation of implants or cell therapies for muscle regeneration.

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