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Technologies 16

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• Meat Alternative from Vegetable Protein
  Nearly 60% of greenhouse gas emissions are linked to the production and processing of meat. Using Wyss-developed technology, an alternative meat can be made from vegetable protein that has the same taste and texture as animal products.
• PhonoGraft^TM: Biomimetic Hearing-restoration Technology
  PhonoGraft is an eardrum-regenerating device that enables better and longer-lasting eardrum reconstruction, reducing the need for invasive surgeries and minimizing the risk of long-term hearing loss. Wyss startup Beacon Bio was acquired by Desktop Health, a healthcare business within Desktop Metal, Inc. which is further developing this technology towards commercialization with the former Wyss startup team leading the way.
• Microrobotic Laser-Steering Medical Device for Minimally Invasive Surgery
  Endoscopy has proven extremely useful in many areas of medicine because it can be carried out with relatively few risks in a short time, and be used to diagnose and treat numerous diseases. In gastroenterology, endoscopies of the upper gastrointestinal tract (esophagus, stomach, first part of the small intestine; upper GI endoscopies) and lower gastrointestinal...
• Cellular “Backpacks” to Slow Tumor Growth
  Macrophages are the body’s multipurpose defense agents, patrolling for pathogens and engulfing cellular debris, foreign substances, microbes, and even cancer cells. But cancerous tumors have evolved an insidious defense mechanism: they can switch arriving macrophages from an anti-cancer state to a pro-cancer state, in which they help promote the tumor’s growth. As a result, attempts...
• Rapid Metabolite-Sensing System for Blood Lactate
  In emergency medicine, blood lactate levels are a reliable real-time indicator of the severity and mortality risk of conditions that occur as a result of poor blood circulation and oxygen supply to organs and tissues (hypoperfusion), such as in patients with sepsis, cardiac arrest, stroke, major trauma, cystic fibrosis and other conditions. Lactate levels also...
• OMNIVAX: Broadly Deployable Infection Vaccine Platform
  OMNIVAX is an immuno-material-based vaccine platform technology able to create safe and effective therapeutic and prophylactic vaccines against viral and bacterial threats. Its modular approach enables the rapid creation of vaccines for pathogens using known and unknown antigens. Current approaches include vaccines against some viral diseases.

Collaborations 1

• i3 Center: Biomaterials to Create T Cell Immunity
  Cancer immunologists and biological engineers are developing new biomaterials-based approaches to develop new anti-cancer immunotherapies for treatment-resistant cancers.

News 120

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• Video/​Animation
  
  A major step forward for organ biofabrication
  July 13, 2022
• Press Release
  
  Deconstructing the mechanics of bone marrow disease
  July 11, 2022
• Research Spotlights
  
  Food-packaging system reduces health risks and saves food
  June 29, 2022

Events 1

• Mar 14, 2019,
  4:30pm
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  From Mechanical Forces to Tissue Straining – How Biophysical Cues Can Be Used to Guide Regeneration: Topics in Bioengineering Seminar
  Harvard John A. Paulson School of Engineering and Applied Sciences Topics in Bioengineering presents this lecture by Georg Duda, Wyss Institute Associate Faculty Member. Conceptually, our research aims at understanding endogenous cascades of tissue formation, cytokine signaling and cellular self-organization especially in bone. Mechanical straining and adaptation due to mechanical cues plays a central role... Free and open to public

Multimedia 40

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  Video/Animation
  coldSNAP: Reimagining Cooling
  We are reimagining air-conditioners to meet increasing global cooling demand while combatting climate change. cold-SNAP is a new technology that uses advanced materials science and design to make affordable, environmentally-positive eco-friendly air conditioners that work in most climates without the use of synthetic refrigerants. Credit: Wyss Institute at Harvard Univesrity

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  Video/Animation
  Janus Tough Adhesives for Tendon Repair
  There is a large unmet need for tendon regeneration therapies after injury. Building upon the tough gel adhesive technologies developed at the Wyss Institute at Harvard University and the Harvard School of Engineering and Applied Sciences, researchers from these institutions collaborated with a group at Novartis to create the Janus Tough Adhesives (JTAs). This two-sided...

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  Video/Animation
  Soft Robots Aiding the Elderly and People with Physical Impairments
  An interdisciplinary team at Harvard University School of Engineering and the Wyss Institute at Harvard University is building soft robots for older adults and people with physical impairments. Examples of these robots are the Assistive Hip Suit and Soft Robotic Glove, both of which have been included in the 2021-2022 Smithsonian Institution exhibit entitled “FUTURES.”...

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  Video/Animation
  PhonoGraft: Programming the eardrum to repair itself
  Eardrum perforations are a widespread problem affecting millions worldwide. Current standard of care is invasive, involves harvesting an autologous tissue to patch the eardrum, and often requires to revision surgeries, while hearing outcomes remain unsatisfying. What if we could program the eardrum to repair itself after injury? Researchers at the Wyss Institute, Massachusetts Eye and...

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  Video/Animation
  A Laser Steering Device for Robot-Assisted Surgery
  Responding to an unmet need for a robotic surgical device that is flexible enough to access hard to reach areas of the G.I. tract while causing minimal peripheral tissue damage, Researchers at the Wyss Institute and Harvard SEAS have developed a laser steering device that has the potential to improve surgical outcomes for patients. Credit:...

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  Video/Animation
  Origami Miniature Surgical Manipulator
  Researchers from the Wyss Institute, Harvard SEAS, and Sony have created the mini-RCM, a small surgical robot that can help surgeons perform delicate teleoperated procedures on the human body. Credit: Wyss Institute at Harvard University