Focus Area: 3D Organ Engineering
64 Results for '3D Organ Engineering'
- Technologies (4)
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Technologies 4
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Engineering organoids to recapitulate brain tissue
The ability to derive and manipulate pluripotent stem cells has opened up new avenues for modeling biological systems in both healthy and diseased conditions. In order to more fully recapitulate the tissue microenvironment with its cell-cell, cell-extracellular matrix, and cell-niche interactions, it is essential to transition stem-cell culturing from monolayers to 3D structures. Self-organization of... -
Human Organs-on-Chips
Clinical studies take years to complete and testing a single compound can cost more than $2 billion. Meanwhile, innumerable animal lives are lost, and the process often fails to predict human responses because traditional animal models often do not accurately mimic human pathophysiology. For these reasons, there is a broad need for alternative ways to... -
JetValve for Heart Regeneration
The human heart beats approximately 35 million times every year, pumping blood into the circulation via four different heart valves. In more than four million people each year, heart valves fail for different reasons, including birth defects, age-related deteriorations and infections. At present, clinicians use either artificial prostheses or fixed animal and cadaver-sourced tissue to... -
3D Bioprinting of Living Tissues
Progress in drug testing and regenerative medicine could greatly benefit from laboratory-engineered human tissues built of a variety of cell types with precise 3D architecture. But production of greater than millimeter sized human tissues has been limited by a lack of methods for building tissues with embedded life-sustaining vascular networks. In this video, the Wyss...
News 40
Multimedia 20
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Audio/PodcastDisruptive: 3D BioprintingThere are roughly 120,000 people in the United States on waiting lists for live-saving organ transplants, with only about 30,000 transplants happening every year. To address this great challenge of organ shortages, a team at the Wyss Institute led by Core Faculty member Jennifer Lewis, Sc.D., is developing a method for 3D bioprinting organ tissues... -
Video/AnimationA Swifter Way Towards 3D-printed Organs20 people die waiting for an organ transplant every day in the US, but lab-grown organs so far lack the cellular density and functions required to make them viable replacements. The new SWIFT method from the Wyss Institute and Harvard SEAS solves those problems by 3D printing vascular channel networks directly into living tissue constructs,... -
Video/AnimationKidney Organiods: Flow-Enhanced Vascularization and Maturation In VitroThis video explains how the collaborative project created vascularized kidney organoids and how they advance the field of tissue engineering. Credit: Wyss Institute at Harvard University. -
Video/AnimationAcoustophoretic PrintingHavard researchers have developed acoustophoretic printing, a method that uses 3D printing technology and highly localized sound waves to generate of droplets with defined sizes and a wide range of viscosities. -
Video/AnimationThis is Your Brain on ChipsHow do you study something as complex as the human brain? Take it apart. Wyss researchers have created Organ Chips that mimic the blood-brain barrier and the brain and, by linking them together, discovered how our blood vessels and our neurons influence each other. Credit: Wyss Institute at Harvard University -
Video/AnimationNew Wyss Institute Initiative – 3D Organ EngineeringWyss Institute Core Faculty members Christopher Chen and Jennifer Lewis describe the Wyss Institute’s new initiative focused on organ engineering, which leverages our expertise in biomaterials, tissue engineering, three dimensional biofabrication, and stem cell development.