Focus Area: 3D Organ Engineering

Technologies 3

• Regenerating heart valves
  The human heart beats approximately 35 million times every year, pumping blood into the circulation via four different heart valves. In more than four million people each year, heart valves fail for different reasons, including birth defects, age-related deteriorations and infections. At present, clinicians use either artificial prostheses or fixed animal and cadaver-sourced tissue to...
• Human Organs-on-Chips
  Clinical studies take years to complete and testing a single compound can cost more than $2 billion. Meanwhile, innumerable animal lives are lost, and the process often fails to predict human responses because traditional animal models often do not accurately mimic human pathophysiology. For these reasons, there is a broad need for alternative ways to...
• 3D Bioprinting of Living Tissues
  Progress in drug testing and regenerative medicine could greatly benefit from laboratory-engineered human tissues built of a variety of cell types with precise 3D architecture. But production of greater than millimeter sized human tissues has been limited by a lack of methods for building tissues with embedded life-sustaining vascular networks. In this video, the Wyss...

News 25

View all

• Image Dangerous cell detachment decoded
  August 15, 2017
• Press Release Engineering heart valves for the many
  May 18, 2017
• Awards Jennifer Lewis elected to National Academy of Engineering
  February 9, 2017

Multimedia 2

• 

  Video/Animation
  3D Printed Heart-on-a-Chip
  In this video, learn how Wyss Institute and Harvard SEAS researchers have created a 3D-printed heart-on-a-chip that could lead to new customizable devices for short-term and long-term in vitro testing. Credit: Johan U. Lind (Disease Biophysics Group), Alex D. Valentine and Lori K. Sanders (Lewis Lab)/Harvard University

• 

  Video/Animation
  Bioprinting: The Kidney’s Proximal Tubules
  In this video, see how the Wyss Institute team has advanced bioprinting to the point of being able to fabricate a functional subunit of a kidney. Credit: Wyss Institute at Harvard University