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• Scientist I-Brain Delivery Technologies
  Research and Technology Development

  The Wyss Institute’s Brain Targeting Program (BTP), co-led by James Gorman, M.D., Ph.D. and Donald Ingber, M.D., Ph.D., is developing brain delivery technologies that enable the development of safer and more effective brain-targeted therapeutics for diverse brain diseases. Our brain delivery platform enables these therapeutic advances by dramatically improving transport of drugs across the blood-brain barrier (BBB) into the brain. We are looking for a talented Scientist to support the development of our novel brain shuttle target identification and validation platform. Reporting to the Senior Director of Translational R&D and the Novel Shuttle Target Lead, you will work as part of a collaborative team to identify novel shuttle targets and contribute to their validation. Your role will involve optimizing and developing assays for protein expression analysis as well as in vitro and in vivo transport validation to advance brain-targeted drug delivery efforts. [68159BR]

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• Development Assistant, Strategic Engagement
  Business Development and Technology Translation

  About the Wyss:

  The Wyss Institute’s mission is to transform healthcare and the environment by emulating the way nature builds. We harness the imagination of academia and the focus of industry to translate ground-breaking technologies into commercial products that solve big problems. We support research that universities, companies, and venture capital firms don’t fund because they view it as too risky.  We prefer to use the word “challenging,” and we love challenges. For more information discover our technologies, catch up on our recent news, or watch our latest videos.

  About Strategic Engagement:

  Each day the Wyss Institute discovers new breakthrough technologies that have the potential to dramatically improve our world within our own lifetimes and need support to leave the lab to realize that potential. Strategic Engagement (SE) works with philanthropic visionaries to ensure that our vibrant community of scientists, clinicians, business leaders, and futurists have the support and freedom they need to conduct this critical interdisciplinary work through innovation and entrepreneurship.

  Role Description:

  The Wyss is looking for a collaborative, out-of-the-box thinker with interest in science, engineering, venture capitalism, and start-up companies to join our Strategic Engagement Team. Strategic Engagement works with philanthropic visionaries to ensure that our vibrant community of scientists, clinicians, business leaders, and futurists have the support and freedom they need to conduct this critical interdisciplinary work through innovation and entrepreneurship. In this role, you will support philanthropy activities by supporting our CRM integration process and gain experience in prospect research techniques data management.

  What you’ll do:

  • Gain an understanding of philanthropy/development office work, including workflows, sources of information, and industry-standard practices, with hands-on support.
  • Utilize databases and tools to conduct prospect research.
  • Support CRM adoption (HubSpot) by developing documentation for best practices and contributing to data integrity.
  • Apply new standards to existing data.
  • Collaborate in an interdisciplinary setting to meet project milestones.
  • Attend regular meetings and training sessions as needed.
  • Maintain confidentiality of sensitive information.

  What you’ll need:

  • Enrolled in or recently graduated from an undergraduate program, with related experience or coursework preferred.
  • Strong organizational skills with excellent analytical, problem solving and critical thinking skills, including an ability to approach problems in a detailed manner while maintaining the big picture.
  • Ability to learn and use library resources after training.
  • Strong planning and excellent follow-up management skills required.
  • Strong interpersonal and communication skills.
  • Passionate, responsible, pro-active, with an ability to thrive in an interdisciplinary team environment.
  • Proficiency in Microsoft Office Suite products and interest in advancing skills when necessary for completion of projects.
  • Experience working in prospect research, development, or other philanthropy roles a plus but not required.

  Compensation: $20 – 22/hour

  Work format details:

  Part-time position, 2 days (14 hours) per week.

  Duration: 3-month temporary assignment with the possibility of extension.

  Role is hybrid on-site and remote, with some on site work required.  Any remote work must be performed in a state in which Harvard is registered to do business.  (CA, CT, GA, IL, MA , MD, ME, NH, NH, NY, RI, VA, VT and WA).

  Where you can apply:

  Please send your resume and cover letter to faculty_postdocs@wyss.harvard.edu using the subject line, “Development Assistant”.

  Harvard University is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions, or any other characteristic protected by law. Demonstrates a commitment to diversity, inclusion, and cultural awareness through actions, interactions, and communications with others.

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• Postdoctoral Fellow – Immunology
  Academic Position

  About the Wyss:

  The mission of the Wyss Institute for Biologically Inspired Engineering at Harvard University is to transform human healthcare and the environment by emulating the way nature builds. Developed as an alliance between Harvard and other premier academic and clinical partner institutions, Institute faculty and staff collaborate in high-risk, fundamental research and science-driven technology development. A major focus of the Institute is to translate the technologies developed by its faculty and staff into commercial products and therapies through collaborations with clinical investigators and establishment of corporate alliances. For more information, discover our technologies, catch up on our recent news, or watch our latest videos.

  Role Description:

  The Wyss Institute for Biologically Inspired Engineering at Harvard University seeks outstanding postdoctoral applicants with expertise in immunology, specifically non-human primates or adoptive cell therapies to join an interdisciplinary team of biologists and engineers to leverage in vitro organ-on-a-chip (Organ Chip) microfluidic culture systems and injectable formulations to study and model adaptive immunity in vaccines, radiation toxicity, Lyme disease and lung and female reproductive tract cancers.  The position is within a team lead by Dr. Don Ingber and Dr. Girija Goyal which is developing model systems to help pharma and regulatory authorities make better decisions and therapies and therapies to treat these diseases. In addition to contributing to or leading the publication of research articles, this role provides the opportunity to present your research to regulatory agencies, investors, pharma companies etc. This role may also provide the opportunity to join a spin-out company as part of the founding team.

  What You’ll Need:

  • Ph.D. or M.D. and have a proven record of high-quality publications in immunology
  • Strong interest in working with multidisciplinary teams (engineers, biologists/physiologists, clinicians) is critical for this position
  • Expertise in in vitro culture of primary human or non-human primate cells or in vivo experiments in mice, as well as knowledge of basic molecular and cell biology concepts and techniques

  Preferred Qualifications:

  • Expertise in adoptive cell therapies or vaccinology or radiation toxicity or cancer immunotherapy
  • Experience in structuring and writing research articles
  • Mentoring experience with research assistants, interns or other early career trainees
  • Comfortable combining creative exploration with R&D milestones

  Benefits and Perks:

  • Medical/Dental/Vision: We offer a variety of excellent medical, dental, & vision plans. All coverage begins as of your start date.
  • Time Off: 20 days of vacation per year
  • Tuition Assistance Program: Competitive tuition assistance program, classes at the Harvard Extension School and discounted options through participating Harvard grad schools.
  • Transportation: Harvard offers a 50% discounted MBTA pass as well as additional options to assist employees in their daily commute.
  • Wellness Options: Harvard offers programs and classes at little or no cost, including stress management, nutrition, meditation, and complimentary health services.

  Where You Can Apply:

  Applications, assembled as single PDF files, should contain a complete resume, cover letter describing research interests and goals, full list of publications, copies of up to three relevant scientific papers, as well as the names and contact information of three references. Applications should be sent to faculty_postdocs@wyss.harvard.edu using the subject line “IMMUNOLOGY POSTDOC APPLICATION.”

  Harvard University is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions, or any other characteristic protected by law. Demonstrates a commitment to diversity, inclusion, and cultural awareness through actions, interactions, and communications with others.

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• Visiting Graduate Researcher – Brain-Targeted Nanoparticles
  Academic Position

  Role Description:

  The Wyss Institute for Biologically Inspired Engineering at Harvard University invites applications for a Visiting Graduate Researcher position in the Brain Targeting Program (BTP). The Wyss Institute’s BTP, co-led by James Gorman, M.D., Ph.D. and Donald Ingber, M.D., Ph.D., is pursuing multiple projects directed to improved methods of transport across the blood-brain barrier (BBB) into the brain, with the aim of improving treatments for diverse diseases of the central nervous system.

  The applicant is expected to participate in the research topic “Brain-targeted nanoparticles: Better treatment of brain diseases”. This project aims to discover a brain-targeted nanoparticle platform to effectively transport a variety of therapeutics across the BBB into the brain.

  The applicant should have basic knowledge of Neuroscience, Cell and Molecular Biology, and basic laboratory experimental skills. The applicant is expected to perform quantification assays such as PCR, ELISA, Western Blot, IHC, and others with training and guidance. The candidate will have one primary mentor, receive rigorous training and exposure to multiple disciplines, and gain in-depth knowledge about the BBB and brain shuttle discovery, preparing them to pursue academic or biopharmaceutical careers.

  In This Role You Will:

  • Participate in the entire process of in vivo animal pharmacokinetic/pharmacodynamic (PK/PD) studies to evaluate the uptake and biodistribution of brain shuttles.
  • Design and execute in vitro experiments to validate the binding of brain shuttles to their targets.
  • Learn cutting-edge technologies and research in the field of brain shuttles and brain-targeted therapeutics.
  • Summarize, present, and share key findings with an interdisciplinary scientific team in a compelling, organized manner.
  • Collaborate with other researchers to address and solve new challenges and unanticipated problems as they arise.
  • Work semi-independently in a detail-oriented, self-driven manner.

  What You’ll Need:

  • Applicants must be in a degree granting graduate program in the field of Biology, Neuroscience, Bioengineering, Pharmaceutical sciences, or a closely related discipline, OR have a fellowship to support post-graduate research.
  • Ph.D. holders are not eligible for this position.
  • Scientific skills: Basic experimental skills such as PCR, ELISA, Western Blot, and IHC. Experience with tissue cryosectioning and/or flow cytometry is a strong plus.
  • Computer skills: Microsoft Office. ImageJ, GraphPad, and other scientific software are helpful.
  • Soft skills: logical thinking, effective communication, adaptability, and self-driven.

  Please Note:  This position is unpaid. The applicant must be enrolled in a degree program for the duration of their visit and must receive academic credit for this experience.  They must also be able to fund their own travel and living expenses or have secured an external source of fellowship support.

   

  Where You Can Apply:

  Applications, assembled as a single PDF file, should contain a complete resume and a cover letter describing research interests, goals, and why you would be a good fit for this program. Applications should be sent to faculty_postdocs@wyss.harvard.edu using the subject line, “Brain-targeted nanoparticles Visiting Graduate Researcher.”

   

  EEO Statement:

  We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions, or any other characteristic protected by law.

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• Postdoctoral Fellow – Aryl hydrocarbon receptor
  Academic Position

  About the Wyss:

  The mission of the Wyss Institute for Biologically Inspired Engineering at Harvard University is to transform human healthcare and the environment by emulating the way nature builds. Developed as an alliance between Harvard and other premier academic and clinical partner institutions, Institute faculty and staff collaborate in high-risk, fundamental research and science-driven technology development. A major focus of the Institute is to translate the technologies developed by its faculty and staff into commercial products and therapies through collaborations with clinical investigators and establishment of corporate alliances. For more information, discover our technologies, catch up on our recent news, or watch our latest videos.

  Role Description:

  Postdoctoral research fellowship to study the role of the aryl hydrocarbon receptor (AHR) in mediating tissue homeostasis and repair, relevant to the development and treatment of inflammatory bowel disease and atherosclerosis, as well as cancer immunity. The project will focus on the evaluation of AHR as a modulator of immune and inflammatory mediated disorders, protein interaction networks, cell metabolism, and tissue repair using animal models and organoid assay systems (Science Advances 2020; 6:eaay8230). The candidate is expected to closely interact with an interdisciplinary team of immunologists, medicinal chemists, pathologists, and biomedical engineers. PhD in molecular or cell biology, immunology, biomedical engineering or related discipline required.

  What you’ll do:

  • Integrate knowledge from immunology, protein interaction networks and cell metabolism to identify immune mediated approaches that promote tissue repair.
  • Initiate and direct experiments that utilize murine models and other organoid models.
  • Integrate knowledge from immunology, protein interaction networks, cell metabolism, molecular and cell biology, to define underlying mechanisms of inflammatory bowel disease, atherosclerosis, or cancer immunity.
  • Apply a variety of in vitro tools, including organoid assays and conduct molecular and cellular bioassays, flow cytometry, as well as other assay systems.

   What you’ll need:

  • Requires a Ph.D. in immunology, biological and biomedical sciences, biomedical engineering or related discipline.
  • Collaborate with members of a multidisciplinary team to efficiently pursue novel strategies that support the discovery of immune modulators for tissue repair and regeneration.
  • Experience in cell and molecular biology, flow cytometry, other complex bioassays, as well as in vivo studies using mouse models.
  • Must be an energetic, out-of-box thinker with positive attitude. Excellent written and oral communication skills are required, as is the desire and ability to work in a multidisciplinary environment.
  • Expert knowledge of scientific principles and concepts. Demonstrated success as exemplified by peer-reviewed publications, scientific creativity, and independent thought.

  Where you can apply:

  Interested candidates should submit a CV and the names of three references to Elliott L. Chaikof, MD, PhD, Johnson and Johnson Professor of Surgery, Harvard Medical School, Beth Israel Deaconess Medical Center, echaikof@bidmc.harvard.edu

  • Chaikof Lab
  • Harvard-MIT Division of Health Sciences and Technology
  • Wyss Institute for Biologically Inspired Engineering
  • Harvard Stem Cell Institute
  • Harvard Medical School

  The Chaikof lab is located in the Center for Life Sciences (CLS) Building in the Longwood medical area, directly adjacent to Harvard Medical School. CLS 11090, 3 Blackfan Circle, Boston, MA 02115.

  Working Conditions:

  Harvard University is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions, or any other characteristic protected by law. Demonstrates a commitment to diversity, inclusion, and cultural awareness through actions, interactions, and communications with others.

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