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Technologies 2

• MRBL: Next-Generation Gene Therapy for Molecular Skin Rejuvenation
  The next-generation gene therapy for molecular skin rejuvenation combines a comprehensive target gene prediction with a novel transdermal delivery approach for therapeutic adenovirus-associated viruses. The platform targets monogenic disease indications in the skin, and extends the same targets to the treatment of common skin aging conditions.
• Synthetic AAV Capsids for Advanced Gene Therapy
  The protein shell (capsid) of Adeno-associated viruses (AAV) are presently the most promising delivery vehicles for various in vivo gene therapies. AAVs are non-pathogenic and, through past engineering efforts, have become safe due to their inability to integrate into and damage the genome of target cells. Rather, the delivered DNA containing a therapeutic gene of...

News 10

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• Community
  
  Denitsa Milanova on MRBL – Gene Therapy for Skin Rejuvenation
  March 25, 2021
• Press Release
  
  Machine-learning how to create better AAV gene delivery vehicles
  February 11, 2021
• Press Release
  
  A new vision for AAV-delivered gene therapies
  February 10, 2021

Multimedia 2

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  Video/Animation
  Improving Canine Healthspan
  A Wyss Institute technology that can treat multiple age-related diseases is now being developed by Rejuvenate Bio into a treatment for mitral valve disease and other deadly conditions in dogs, with the goal of helping man’s best friend live longer, healthier lives. Credit: Wyss Institute at Harvard University

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  Video/Animation
  AAV Capsid Engineering
  Wyss researchers have created a high-throughput platform to generate an Adeno-associated virus 2 (AAV2) library containing 200,000 variants, each carrying a distinct mutation in the virus capsid protein. Their analysis identified capsid changes that enhanced “homing” potential to specific organs in mice and virus viability, as well as a new protein hidden in the capsid-encoding...

Events 1

• May 16 → 19, 2018 Workshop
  
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  ASGCT Annual Meeting
  Wyss Core Faculty member George Church and Wyss team members Eric Kelsic, Kai Chan and Pierce Ogden will speak about their work on AAV capsid engineering as part of this year’s American Society of Gene and Cell Therapy Annual Meeting. Please visit the ASGCT Annual Meeting website, for more information related to the meeting and...