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Technologies 1

• Gene Drives
  Since the 1940s, researchers have thought of using gene drives to eradicate populations of pests and disease vectors, and to reduce or eliminate invasive species that wreak havoc on natural ecosystems. The idea of a gene drive stems from nature itself, where in sexually reproducing organisms a certain version of a gene is preferentially passed...

News 5

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• Translation News
  
  Harvard’s Wyss Institute joins forces with Cytosurge to improve CRISPR-based multiplexed gene editing
  May 4, 2020
• Awards
  
  Tina Liu Wins Women World Award
  August 9, 2019
• Press Release
  
  Recording every cell’s history in real-time with evolving genetic barcodes
  August 9, 2018

Multimedia 5

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  Video/Animation
  CRISPR-Cas9: Safeguarding Gene Drives
  In this animation, learn how effective safeguarding mechanisms developed at the Wyss Institute and Harvard Medical School can be applied to ensure gene drive research is done responsibly in the laboratory. These safeguards enable responsible scientific investigation into how gene drives could one day be leveraged for the greater good of human health, agriculture, and...

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  Video/Animation
  CRISPR-Cas9: Gene Target Troubleshooting
  In this animation, learn how a “library on library” approach was used to create a software algorithm that can predict the best way to target any specific gene. Using the most effective RNA sequence, which can be selected using the novel software’s ranking and scoring algorithm, the gene editing mechanism known as CRISPR-Cas9 can be...

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  Video/Animation
  Cas9: As a Transcriptional Activator
  In this technical animation, Wyss Institute researchers instruct how they engineered a Cas9 protein to create a powerful and robust tool for activating gene expression. The novel method enables Cas9 to switch a gene from off to on and has the potential to precisely induce on-command expression of any of the countless genes in the...

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  Video/Animation
  Gene Editing Mechanism of CRISPR-Cas9
  In this animation, learn how CRISPR-Cas9 gene editing technology can be used to precisely disrupt and modify specific genes. Credit: Wyss Institute at Harvard University.

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  Video/Animation
  CRISPR-Cas9: Gene Drives
  This animation explains how an emerging technology called “gene drives” may be used to potentially spread particular genomic alterations through targeted wild populations over many generations. It uses mosquitoes as an example of a target species – and illustrates how the versatile genome editing tool called CRISPR makes it possible. Credit: Wyss Institute at Harvard...