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Technologies 6

• DoriVac: Boosting Antigen-specific Immune Responses with DNA Origami-Based Vaccines
  Personalized cancer and infectious disease vaccine platform harnessing DNA nanotechnology to control the co-delivery and co-presentation of tumor antigen and adjuvant ligands to immune cells with nanoscale precision. This approach has potential to trigger enhanced immune responses against tumors and infectious pathogens.
• Crisscross Nanoseed Detection: Nanotechnology-Powered Infectious Disease Diagnostics
  This nanotech-based diagnostic platform uses a unique nucleation mechanism that assembles a DNA "nanoseed" in the presence of a pathogen-derived biomarker that then is amplified within 15 minutes to create a signal for easy detection. It is highly robust, and cost-effective, and can be adapted to detect a variety of biomarkers.
• DNA Nanotechnology Tools: From Design to Applications
  A suite of diverse, multifunctional DNA nanotechnological tools with unique capabilities and potential for a broad range of clinical and biomedical research areas. Our DNA nanotechnology devices were engineered to overcome specific bottlenecks in the development of new therapies and diagnostics, and to help further our understanding of molecular structures.
• DNA Nanostructures for Drug Delivery
  Researchers at the Wyss Institute have developed two methods for building arbitrarily shaped nanostructures using DNA, with a focus on translating the technology towards nanofabrication and drug delivery applications. One proprietary nanofabrication technique, called “DNA-brick self-assembly,” uses short, synthetic strands of DNA that work like interlocking Lego® bricks. It capitalizes on the ability to program...
• Multiplexed Molecular Force Spectroscopy
  Programmable DNA nanoswitches, invented at the Wyss Institute, can now be used in combination with a benchtop Centrifuge Force Microscope (CFM) as a highly reliable tool to observe thousands of individual molecules and their responses to mechanical forces in parallel. By analyzing the responses of single molecules under conditions where they experience such forces, it is possible...
• Inexpensive Super-Resolution Microscopy
  Wyss Institute scientists have developed a highly versatile and inexpensive microscopic imaging platform designed to visualize objects with molecular-scale resolution and unprecedented complexity. The DNA-powered imaging technology can reveal the inner workings of cells at the single molecule level, using conventional microscopes found in most laboratories. Key to the Wyss Institute’s DNA-driven imaging super resolution...

Collaborations 1

• i3 Center: Biomaterials to Create T Cell Immunity
  Cancer immunologists and biological engineers are developing new biomaterials-based approaches to develop new anti-cancer immunotherapies for treatment-resistant cancers.

News 67

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• Press Release
  
  DNA nanostructures grow up to become micron-scale megastructures
  December 21, 2022
• Awards
  
  Elizabeth Carstens and Yang Claire Zeng selected as 3rd recipients of Harvard’s “Immuno-engineering to Improve Immunotherapy” (i3) Center award
  December 14, 2022
• Press Release
  
  Getting to the heart of engineering a heart
  June 8, 2022

Multimedia 21

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  Video/Animation
  Seed-dependent crisscross DNA-origami slats
  This animation explains how the newly invented crisscross origami method can be used to build functionalized micron-scale DNA megastructures composed of many unique DNA origami “slats,” each with their own complexity and interactive properties. Credit: Wyss Institute at Harvard University

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  Video/Animation
  DoriVac: Square Block DNA Origami Vaccine
  This animation explains how DoriVac leverages DNA origami nanotechnology and immune activators to stimulate stronger and long-lasting immune responses against cancer and potentially infectious diseases. Credit: Wyss Institute at Harvard University

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  Video/Animation
  DNA Nanoswitch Calipers
  The world’s tiniest ruler for biomolecules has been created by researchers at the Wyss Institute at Harvard University, Harvard Medical School, and Boston Children’s Hospital. DNA Nanoswitch Calipers can measure very small peptides to better understand their structure and function, and enable them to be quickly identified in mixed samples. These insights could lead to...

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  Exchange-PAINT: Neurons Up Close and Personal
  DNA Exchange Imaging of fixed mouse hippocampal neurons stained sequentially with antibodies recognizing neuronal markers Synapsin I, vGAT, MAP2, pNFH, α-tubulin, acetyl-tubulin, GFAP and nuclear marker DAPI. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Primer Exchange Reaction
  In this video, Jocelyn Kishi illustrates how Primer Exchange Reaction (PER) cascades work to autonomously create programmable long single-stranded DNA molecules. Credit: Wyss Institute at Harvard University.

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  Video/Animation
  What Is BIOMOD?
  BIOMOD is a biomolecular design competition for students created by the Wyss Institute for Biologically Inspired Engineering at Harvard University. Each year BIOMOD holds a Jamboree, an annual conference at which all BIOMOD teams convene to present their work from the summer. This year’s Jamboree will take place in Genentech Hall at UCSF in San Francisco,...