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Technologies 3

• DNA Nanoswitch Calipers for Single-Molecule Proteomics
  DNA nanoswitch calipers are a first-of-their-kind research tool that leverage DNA’s unique molecular qualities to study post-translational modifications on proteins to unlock a new frontier of medicine.
• DNA Nanoswitches: “Lab-on-a-Molecule” Drug Discovery
  The Lab-on-a-Molecule platform leverages the Wyss Institute’s DNA nanotechnology technology for the high-throughput, low-cost screening of a wide range of chemical and biologic compounds to enable the discovery of first-in-class therapeutics for various conditions.
• DNA Nanotechnology Tools: From Design to Applications
  A suite of diverse, multifunctional DNA nanotechnological tools with unique capabilities and potential for a broad range of clinical and biomedical research areas. Our DNA nanotechnology devices were engineered to overcome specific bottlenecks in the development of new therapies and diagnostics, and to help further our understanding of molecular structures.

News 8

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• Press Release
  
  FINDing new drug leads faster with DNA nanotechnology
  November 5, 2026
• Community
  
  Evolving how we use DNA through nanotechnological innovations
  April 25, 2024
• Press Release
  
  Wyss Institute’s Lab-on-a-Molecule Drug Discovery Project Receives Funding from Northpond Labs
  April 4, 2023

Multimedia 1

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  Video/Animation
  DNA Nanoswitch Calipers
  The world’s tiniest ruler for biomolecules has been created by researchers at the Wyss Institute at Harvard University, Harvard Medical School, and Boston Children’s Hospital. DNA Nanoswitch Calipers can measure very small peptides to better understand their structure and function, and enable them to be quickly identified in mixed samples. These insights could lead to...