11 Results for 'DNA synthesis'
MAGE: Multiplex Automated Genomic Engineering
Developed at the Wyss Institute, MAGE harnesses the natural principles of evolution to do all the heavy lifting of genome design and automates these steps to dramatically shorten the time scale required to produce microbes with specialized functionalities for manufacturing, sensing and therapeutic applications. Genome engineering has a wide range of applications, from developing new...
Video/AnimationAAV Capsid EngineeringWyss researchers have created a high-throughput platform to generate an Adeno-associated virus 2 (AAV2) library containing 200,000 variants, each carrying a distinct mutation in the virus capsid protein. Their analysis identified capsid changes that enhanced “homing” potential to specific organs in mice and virus viability, as well as a new protein hidden in the capsid-encoding...
Video/AnimationCRISPR-Cas: Molecular RecordingIn this video, Wyss Institute and Harvard Medical School researchers George Church and Seth Shipman explain how they engineered a new CRISPR system-based technology that enables the chronological recording of digital information, like that representing still and moving images, in living bacteria. Credit: Wyss Institute at Harvard University