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Technologies 1

• Inexpensive Super-Resolution Microscopy
  Wyss Institute scientists have developed a highly versatile and inexpensive microscopic imaging platform designed to visualize objects with molecular-scale resolution and unprecedented complexity. The DNA-powered imaging technology can reveal the inner workings of cells at the single molecule level, using conventional microscopes found in most laboratories. Key to the Wyss Institute’s DNA-driven imaging super resolution...

News 13

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• Press Release
  
  DNA nanostructures grow up to become micron-scale megastructures
  December 21, 2022
• Research Spotlights
  
  DNA: From blueprint to blank slate
  April 23, 2021
• Press Release
  
  Painting the molecular canvas in super-resolution
  September 16, 2019

Multimedia 3

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  Video/Animation
  Seed-dependent crisscross DNA-origami slats
  This animation explains how the newly invented crisscross origami method can be used to build functionalized micron-scale DNA megastructures composed of many unique DNA origami “slats,” each with their own complexity and interactive properties. Credit: Wyss Institute at Harvard University

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  Exchange-PAINT: Neurons Up Close and Personal
  DNA Exchange Imaging of fixed mouse hippocampal neurons stained sequentially with antibodies recognizing neuronal markers Synapsin I, vGAT, MAP2, pNFH, α-tubulin, acetyl-tubulin, GFAP and nuclear marker DAPI. Credit: Wyss Institute at Harvard University

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  Video/Animation
  DNA Cages
  To create supersharp images of their cage-shaped DNA polyhedra, the scientists used DNA-PAINT, a microscopy method that uses short strands of DNA (yellow) labeled with a fluorescent chemical (green) to bind and release partner strands on polyhedra corners, causing them to blink. The blinking corners reveal the shape of structures far too small to be...