23 Results for 'DNA'
DNA Data Storage
The genetic material DNA has garnered considerable interest as a medium for digital information storage because its density and durability are superior to those of existing silicon-based storage media. For example, DNA is at least 1000-fold more dense than the most compact solid-state hard drive and at least 300-fold more durable than the most stable...
INSPECTR™: Direct-to-Consumer Molecular Diagnostic
INSPECTR™ is a molecular diagnostic platform that combines freeze-dried synthetic gene networks with cell-free expression systems to create novel biosensors that detect and report the presence of a target DNA or RNA molecule without the need for power or lab equipment. This technology was licensed by Wyss startup Sherlock Biosciences in 2019.
Multiplexed Molecular Force Spectroscopy
Programmable DNA nanoswitches, invented at the Wyss Institute, can now be used in combination with a benchtop Centrifuge Force Microscope (CFM) as a highly reliable tool to observe thousands of individual molecules and their responses to mechanical forces in parallel. By analyzing the responses of single molecules under conditions where they experience such forces, it is possible...
Inexpensive Super-Resolution Microscopy
Wyss Institute scientists have developed a highly versatile and inexpensive microscopic imaging platform designed to visualize objects with molecular-scale resolution and unprecedented complexity. The DNA-powered imaging technology can reveal the inner workings of cells at the single molecule level, using conventional microscopes found in most laboratories. Key to the Wyss Institute’s DNA-driven imaging super resolution...
MAGE: Multiplex Automated Genomic Engineering
Developed at the Wyss Institute, the multiplex automated genome engineering (MAGE) technology harnesses the natural principles of evolution to do all the heavy lifting of genome design and automates these steps to dramatically shorten the time scale required to produce microbes with specialized functionalities for manufacturing, sensing and therapeutic applications. Genome engineering has a wide...
Audio/PodcastXenotransplantation – The Naked Scientists Podcast with George ChurchAmidst the aftermath of COVID-19 waiting lists continue to grow for those in need of an organ transplant, whilst simultaneously in an American surgery a man receives the heart of a pig. Animal donors may be the answer to our shortage of available organs, but the procedure isn’t quite ready to become common place. Take...
Video/AnimationEnzymatic DNA Synthesis (EDS) for Data StoragePostdoctoral Fellow, Henry Lee, presents a Wyss Institute Validation Project that is developing a sustainable, low-cost approach for writing large amounts of digital information in DNA. This could one day replace current data storage methods, which are energy intensive and use large amounts of nonrenewable resources. Credit: Wyss Institute at Harvard University
Video/AnimationPrimer Exchange ReactionIn this video, Jocelyn Kishi illustrates how Primer Exchange Reaction (PER) cascades work to autonomously create programmable long single-stranded DNA molecules. Credit: Wyss Institute at Harvard University.
Video/AnimationDNA NanoswitchesGel electrophoresis, a common laboratory process, sorts DNA or other small proteins by size and shape using electrical currents to move molecules through small pores in gel. The process can be combined with novel DNA nanoswitches, developed by Wyss Associate Faculty member Wesley Wong, to allow for the simple and inexpensive investigation of life’s most...