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Technologies 26

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• AminoX: Making Biologics Safer with Synthetic Biology and Advanced Chemistry
  AminoX enables protein drugs to only become active in the tumor microenvironment and not elsewhere in the body to avoid immune-related adverse effects in the body. By designing and building non-standard amino acids into strategic positions of protein drugs, AminoX provides tumor-specific, and longer-lasting target inhibition.
• HarborSite: Precise and Efficient Gene Editing for Next-Generation Gene Therapies
  The HarborSite next-generation gene therapy platform enables integration of therapeutic genes into genomic safe harbors using highly specific and efficient recombinases to enable more predictable, safe and durable gene therapies.
• DNA Nanoswitches: “Lab-on-a-Molecule” Drug Discovery
  The Lab-on-a-Molecule platform leverages the Wyss Institute’s DNA nanotechnology technology for the high-throughput, low-cost screening of a wide range of chemical and biologic compounds to enable the discovery of first-in-class therapeutics for various conditions.
• Pancreatitis Tx: An Engineered Protein Treatment for Pancreatitis
  First disease-modifying therapy that can be systemically applied to safely and effectively treat patients with different forms of pancreatitis.
• Sparkle: Instant Biosensors for Real-Time Imaging
  Sparkle is revolutionizing the binder assay industry by harnessing novel chemistry to create instant fluorescent biosensors for a wide variety of uses.
• CogniXense for Rare Disease Drug Discovery
  Unravel Biosciences has licensed a Wyss drug discovery platform technology to identify and create drugs to treat complex central nervous system disorders, starting with Rett syndrome.

Collaborations 3

• Brigham-Wyss DxA
  The Wyss DxA's clinical partners from Brigham and Women’s Hospital identify the most pressing unmet diagnostic needs, provide access to high-quality patient samples for our Biomarker Discovery Laboratory (BDL) and Brigham-Wyss DxA collaborators, and provide invaluable feedback and guidance on the engineering and validation of cost-effective, sensitive, and specific diagnostic tests.
• Biomarker Discovery Laboratory (BDL)
  Bridging the diagnostic gap from biomarker discovery to market-ready test kits and instruments through cutting-edge technology development and clinical collaboration.
• Brain Targeting Program
  Pre-competitive multi-partner industry collaboration that aims to identify novel transport targets and shuttle compounds to enable more effective delivery of drugs to the brain.

News 250

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• Community
  
  Jenny Tam on Discovering Better Treatments for Bipolar Disorder
  October 26, 2023
• Awards
  
  Wyss Institute at Harvard University wins BARDA contract to leverage human Organ Chips to advance knowledge and drug discovery for broad range of health security threats
  October 18, 2023
• Press Release
  
  Human Lung Chip leveraged to faithfully model radiation-induced lung injury
  October 17, 2023

Multimedia 73

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  Video/Animation
  Bridging science, engineering, and art: from mechanobiology to Human Organs-on-Chips
  In this Marsilius Lecture, Wyss Founding Director Don Ingber shares his personal path from a serendipitous experience in an undergraduate art class that led to his discovery of how living cells are constructed using “tensegrity” architecture and how this contributed to the birth of the field of Mechanobiology to his more recent work on human...

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  Video/Animation
  Novel Model Organisms w/ Don Ingber & Hans Clevers – BIOS Roundtable
  Don Ingber – Founding Director at Wyss Institute Hans Clevers – Head of Pharma Research & Development (pRED) at Roche Hear about the evolution of humanized models and their potential applications in drug development, personalized medicine, and more. Ingber and Clevers share their scientific experiences and expertise. They also discuss misconceptions surrounding the application of...

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  Video/Animation
  How do we make safer and more effective drugs?
  Wyss researchers are using an ever-growing number of human tissue-mimicking Organ Chips to improve and accelerate the drug development process for a wide number of unmet diseases – and understand what causes them to erupt. More recently, they added a human Vagina Chip and personalized Barrett’s esophagus Chip to their arsenal, and created in vitro...

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  Video/Animation
  How can we better treat brain diseases?
  The Brain Targeting Program at the Wyss Institute is a pre-competitive, multi-partner industry collaboration that aims to identify novel transport targets and shuttle compounds to enable more effective delivery of drugs to the brain. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Reimagining Recovery and Pain Management After Her Injury: Megan Sperry
  Megan Sperry is a Postdoctoral Fellow working on the Biostasis project to help develop therapeutics that could slow down biological time. In this video, she shares a personal story about an injury she suffered after years of figure skating and how she would Reimagine the World with better recovery outcomes and pain management after trauma....

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  Video/Animation
  The Vagina Chip: A New Preclinical Model for Research on Vaginal Epithelium Microbiome Interactions
  The Vagina Chip allows researchers to study a human model of the vaginal microbiome and develop new treatments for bacterial vaginosis and other conditions that threaten women’s health. Credit: Research Square