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201 Results for 'Drug Development'
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Technologies 11
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Microfluidic encapsulation for subcutaneous delivery of viscous drugs
Antibodies and other biopharmaceuticals have emerged as a powerful new class of drugs for treating diseases that range from rheumatoid arthritis to breast cancer to macular degeneration. However, these large, protein-based molecules cannot be taken orally (the stomach would digest them) and are frequently given at high concentrations. Most are administered intravenously, but that approach... -
A broad strategy to reduce the toxicity of protein drugs
Therapeutic variants of the natural hormone erythropoietin (EPO) which is produced in the kidney to boost the production of red blood cells are commonly used to treat anemias stemming from kidney disease, chemotherapy and other complications. However, many drugs that are based on therapeutic proteins, including EPO, often cause unwanted side effects because they not... -
DNA Nanostructures for Drug Delivery
Researchers at the Wyss Institute have developed two methods for building arbitrarily shaped nanostructures using DNA, with a focus on translating the technology towards nanofabrication and drug delivery applications. One proprietary nanofabrication technique, called “DNA-brick self-assembly,” uses short, synthetic strands of DNA that work like interlocking Lego® bricks. It capitalizes on the ability to program... -
Fluorescent In Situ Sequencing (FISSEQ)
Working copies of active genes — called messenger RNAs or mRNAs —translate the genetic information present in DNA into proteins within the cells’ multiple compartments. They are often positioned strategically within cells in ways that contribute critically to how cells and tissues grow, develop and function, and their mislocation can lead to disease development. To... -
Putting Biofilms to Work
A team at the Wyss Institute sees biofilms as a robust new platform for designer nanomaterials that could treat inflammatory bowel diseases, clean up polluted rivers, manufacture pharmaceutical products, fabricate new textiles, and more. A novel protein engineering system called BIND, which stands for Biofilm-Integrated Nanofiber Display, could be the essential ingredient in tomorrow’s probiotic... -
Implantable cancer vaccine
The Wyss Institute’s implantable, biodegradable cancer vaccine leverages immunotherapeutic methods and could one day help overcome melanoma, other cancers, infectious diseases, auto-immune diseases, as well as vaccinate against specific peptides, proteins, or antigens. The implant is a biodegradable polymer scaffold containing growth factors and components of each patient’s tumors. The technology was initially designed to...
News 160
Multimedia 30
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Audio/PodcastDisruptive: Cancer Vaccine & Hydrogel Drug DeliveryIn this episode of Disruptive, Wyss Founding Core Faculty Member Dave Mooney discusses programmable nanomaterials approaches to fighting disease. Mooney explains how a cancer vaccine, developed by his team and currently in a clinical trial at the Dana-Farber Cancer Institute, can train one’s own immune system to target specific cancer cells. He also describes the... -
Video/AnimationGene Editing Mechanism of CRISPR-Cas9In this animation, learn how CRISPR-Cas9 gene editing technology can be used to precisely disrupt and modify specific genes. Credit: Wyss Institute at Harvard University. -
Video/AnimationIntroduction to Organs-on-a-ChipWhat if we could test drugs without animal models? For more information, please visit our technology page: Human Organs-on-Chips Credit: Wind Powered Productions -
Video/AnimationIntroduction to Programmable NanoroboticsWhat if we could build programmable nanorobots to attack disease? Related press release: https://wyss.harvard.edu/researchers-at-harvards-wyss-institute-develop-dna-nanorobot-to-trigger-targeted-therapeutic-responses/ Credit: Wyss Institute at Harvard University -
Video/AnimationDNA Nanorobot: Cell-Targeted, Payload-DeliveringThis video describes a cell-targeted, payload-delivering DNA nanorobot developed at the Wyss Institute that can trigger targeted therapeutic responses. This novel technology could potentially seek out cancer cells and cause them to self-destruct. Related press release: https://wyss.harvard.edu/researchers-at-harvards-wyss-institute-develop-dna-nanorobot-to-trigger-targeted-therapeutic-responses/ Credit: Wyss Institute at Harvard University -
Video/AnimationMagnetic YeastIn this video, Wyss Core Faculty member Pamela Silver describes how her team at the Wyss Institute and Harvard Medical School induced magnetic sensitivity in a non-magnetic organism. This technology could potentially be used to magnetize a variety of different cell types in medical, industrial and research applications. Related press release: https://wyss.harvard.edu/new-magnetic-yeast-could-be-significant-step-in-harnessing-natures-magnetic-capabilities/ Credit: Wyss Institute...