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Technologies 25

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• HarborSite: Precise and Efficient Gene Editing for Next-Generation Gene Therapies
  The HarborSite next-generation gene therapy platform enables integration of therapeutic genes into genomic safe harbors using highly specific and efficient recombinases to enable more predictable, safe and durable gene therapies.
• DNA Nanoswitches: “Lab-on-a-Molecule” Drug Discovery
  The Lab-on-a-Molecule platform leverages the Wyss Institute’s DNA nanotechnology technology for the high-throughput, low-cost screening of a wide range of chemical and biologic compounds to enable the discovery of first-in-class therapeutics for various conditions.
• Pancreatitis Tx: An Engineered Protein Treatment for Pancreatitis
  First disease-modifying therapy that can be systemically applied to safely and effectively treat patients with different forms of pancreatitis.
• Sparkle: Instant Biosensors for Real-Time Imaging
  Sparkle is revolutionizing the binder assay industry by harnessing novel chemistry to create instant fluorescent biosensors for a wide variety of uses.
• CogniXense for Rare Disease Drug Discovery
  Unravel Biosciences has licensed a Wyss drug discovery platform technology to identify and create drugs to treat complex central nervous system disorders, starting with Rett syndrome.
• SPEAR: Ultrasensitive Protein Detection in Small Samples
  Spear Bio uses a DNA nanotechnology-driven approach developed at the Wyss Institute that allows the sensitive detection of protein biomarkers in small samples using standard instruments to create new research and diagnostic assays. An ultra-sensitive assay detecting neutralizing antibodies against SARS-CoV-2 will be the first to be commercialized.

Collaborations 1

• Brain Targeting Program
  Pre-competitive multi-partner industry collaboration that aims to identify novel transport targets and shuttle compounds to enable more effective delivery of drugs to the brain.

News 242

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• Community
  
  From classmates to co-founders
  April 21, 2023
• Press Release
  
  A backpack full of multiple sclerosis therapy
  April 21, 2023
• Press Release
  
  Creating a blueprint for optimized ear tubes and other implantable fluid-transporting devices
  April 5, 2023

Multimedia 70

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  Video/Animation
  How can we better treat brain diseases?
  The Brain Targeting Program at the Wyss Institute is a pre-competitive, multi-partner industry collaboration that aims to identify novel transport targets and shuttle compounds to enable more effective delivery of drugs to the brain. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Reimagining Recovery and Pain Management After Her Injury: Megan Sperry
  Megan Sperry is a Postdoctoral Fellow working on the Biostasis project to help develop therapeutics that could slow down biological time. In this video, she shares a personal story about an injury she suffered after years of figure skating and how she would Reimagine the World with better recovery outcomes and pain management after trauma....

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  Video/Animation
  The Vagina Chip: A New Preclinical Model for Research on Vaginal Epithelium Microbiome Interactions
  The Vagina Chip allows researchers to study a human model of the vaginal microbiome and develop new treatments for bacterial vaginosis and other conditions that threaten women’s health. Credit: Research Square

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  Video/Animation
  Reimagine the World: Volume 1
  Four Wyss Institute scientists, Mariana Garcia-Corral, Pawan Jolly, Megan Sperry, and Mike Super, share how they would Reimagine the World and the personal stories that fuel their passion for the work they are doing. We’d love to hear how you would Reimagine the World! Please visit the following link to share your ideas: https://wyss.typeform.com/to/o9xM7cG1 Credit:...

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  Video/Animation
  SomaCode: GPS for Cell Therapy
  Just like zip codes help drivers navigate to specific addresses using a GPS system, the molecular ‘zip codes’ identified via the SomaCode platform can be used to deliver cell therapies to their specific targets in the human body, increasing the therapies’ efficacy and reducing side effects. Credit: Wyss Institute at Harvard University

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  Audio/Podcast
  Animal Free Labcast #4 – The Pioneer
  World-class pioneer of biomedical research and innovation, Dr. Don Ingber, is the founding director of Harvard University’s Wyss Institute for Biologically Inspired Engineering. In 2010, Dr. Ingber developed a lung-on-a-chip – the first of its kind – and has continued to lead the field by developing numerous other organ chip models, demonstrating their ability to...