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260 Results for 'Drug Development'
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Technologies 16
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Antibody-based targeting of drugs and diagnostics to the brain
In its Brain Targeting Program, a Wyss team led by Founding Director Donald Ingber, M.D., Ph.D. and Staff Program Lead James Gorman, M.D., Ph.D. is developing improved approaches to target drugs and diagnostics to the brain. Leveraging the human blood-brain barrier (BBB) Chip technology developed by Ingber’s team, combined with advanced antibody R&D capabilities, the... -
CogniXense – A high-throughput cognitive screen for modeling disorders on-the-fly
There are more than 6,000 known single-gene disorders, in which a disruption to one gene out of the 20,000 in the human genome is enough to cause significant health effects. In order to study these disorders and develop treatments, a given genetic mutation must first be induced in a large number of animal models (usually... -
abbieSense Anaphylaxis Diagnostic
The molecule histamine plays a primary role in the anaphylaxis reaction, which is a major cause of illness and death in people with severe allergies. Histamine is a very small molecule composed of only seventeen atoms, making it a challenging target to detect. To date, no diagnostic test exists that can measure histamine levels accurately... -
Customizable scaffolds for faster, higher-quality T cell production
Immunotherapy, or tweaking the body’s own immune system to treat disease, is attracting significant attention in the medical field for its potential to offer long-lasting cures with fewer side effects than chemotherapy or other drugs. One type of immunotherapy involves isolating T cells (a type of white blood cell) from a patient’s body, sometimes modifying... -
Toehold Probes
The accurate detection of specific DNA or RNA sequences is important for many research and diagnostic applications, and unspecific detection of similar sequences that can differ by only a single nucleotide can give false positive results. In addition, researchers and clinicians would like to accurately test for presence or absence of multiple single base changes... -
Toehold switches as versatile tools for synthetic biology applications
The burgeoning field of synthetic biology is designing artificial gene circuits that recognize molecules in their environment and respond by regulating genes with desired activities. In the future, such capabilities could allow the engineering of cells as diagnostic or therapeutic devices, factories for the production of clinically or industrially coveted molecules, and as specialized devices...
News 189
Multimedia 55
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Video/AnimationSABER-FISH: Enabling the sensitive and multiplexed detection of nucleic acids within thick tissuesThis animation shows how SABER-FISH uses a suite of DNA nanotechnological methods that together enable the sensitive and multiplexed detection of DNA and RNA targets within cells and thick tissues. Credit: Wyss Institute at Harvard University -
Video/AnimationKidney Organiods: Flow-Enhanced Vascularization and Maturation In VitroThis video explains how the collaborative project created vascularized kidney organoids and how they advance the field of tissue engineering. Credit: Wyss Institute at Harvard University. -
Video/AnimationabbieSenseabbieSense is a Wyss technology that can detect histamine levels in human body fluids and determine the severity of an allergic reaction, which could help save the lives of patients with severe allergies. Credit: Wyss Institute at Harvard University -
Video/AnimationAcoustophoretic PrintingHavard researchers have developed acoustophoretic printing, a method that uses 3D printing technology and highly localized sound waves to generate of droplets with defined sizes and a wide range of viscosities. -
Audio/PodcastDisruptive: Art Advances ScienceIn this episode of Disruptive, Wyss Institute Founding Director Don Ingber and Staff Scientist Charles Reilly discuss their process creating The Beginning, a short film inspired by Star Wars, to better communicate science to the public…and how they made a scientific discovery along the way. To make The Beginning, film industry visual effects and animation... -
Video/AnimationNew Wyss Institute Initiative – 3D Organ EngineeringWyss Institute Core Faculty members Christopher Chen and Jennifer Lewis describe the Wyss Institute’s new initiative focused on organ engineering, which leverages our expertise in biomaterials, tissue engineering, three dimensional biofabrication, and stem cell development.