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242 Results for 'Drug Development'
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Technologies 15
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abbieSense Anaphylaxis Diagnostic
The molecule histamine plays a primary role in the anaphylaxis reaction, which is a major cause of illness and death in people with severe allergies. Histamine is a very small molecule composed of only seventeen atoms, making it a challenging target to detect. To date, no diagnostic test exists that can measure histamine levels accurately... -
Customizable scaffolds for faster, higher-quality T cell production
Immunotherapy, or tweaking the body’s own immune system to treat disease, is attracting significant attention in the medical field for its potential to offer long-lasting cures with fewer side effects than chemotherapy or other drugs. One type of immunotherapy involves isolating T cells (a type of white blood cell) from a patient’s body, sometimes modifying... -
Toehold Probes
The accurate detection of specific DNA or RNA sequences is important for many research and diagnostic applications, and unspecific detection of similar sequences that can differ by only a single nucleotide can give false positive results. In addition, researchers and clinicians would like to accurately test for presence or absence of multiple single base changes... -
Toehold switches as versatile tools for synthetic biology applications
The burgeoning field of synthetic biology is designing artificial gene circuits that recognize molecules in their environment and respond by regulating genes with desired activities. In the future, such capabilities could allow the engineering of cells as diagnostic or therapeutic devices, factories for the production of clinically or industrially coveted molecules, and as specialized devices... -
Human Organs-on-Chips
Clinical studies take years to complete and testing a single compound can cost more than $2 billion. Meanwhile, innumerable animal lives are lost, and the process often fails to predict human responses because traditional animal models often do not accurately mimic human pathophysiology. For these reasons, there is a broad need for alternative ways to... -
Microfluidic encapsulation for subcutaneous delivery of viscous drugs
Because of their large molecular sizes and properties, biologic drugs, be it in the form of monoclonal antibodies that target disease-associated molecules or active proteins and enzymes that may correct deficiencies in the human body, have proven difficult to deploy in many cases. Their therapeutic effects on target cells and tissues often require high and...
News 174
Multimedia 53
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Video/AnimationabbieSenseabbieSense is a Wyss technology that can detect histamine levels in human body fluids and determine the severity of an allergic reaction, which could help save the lives of patients with severe allergies. Credit: Wyss Institute at Harvard University -
Video/AnimationAcoustophoretic PrintingHavard researchers have developed acoustophoretic printing, a method that uses 3D printing technology and highly localized sound waves to generate of droplets with defined sizes and a wide range of viscosities. -
Audio/PodcastDisruptive: Art Advances ScienceIn this episode of Disruptive, Wyss Institute Founding Director Don Ingber and Staff Scientist Charles Reilly discuss their process creating The Beginning, a short film inspired by Star Wars, to better communicate science to the public…and how they made a scientific discovery along the way. To make The Beginning, film industry visual effects and animation... -
Video/AnimationNew Wyss Institute Initiative – 3D Organ EngineeringWyss Institute Core Faculty members Christopher Chen and Jennifer Lewis describe the Wyss Institute’s new initiative focused on organ engineering, which leverages our expertise in biomaterials, tissue engineering, three dimensional biofabrication, and stem cell development. -
Audio/PodcastHow 3D Bioprinting Could Revolutionize Organ ReplacementHow 3D Bioprinting Could Revolutionize Organ Replacement was originally broadcast on WBUR on November 22, 2017. This story features Wyss Core Faculty member Jennifer Lewis. The original broadcast story can be found here. -
Audio/PodcastDisruptive: Cancer Vaccine and Immuno-MaterialsImmunotherapy – treatment that uses the body’s own immune system to help fight disease – has groundbreaking and life-saving implications. In an effort to make immunotherapy more effective, Wyss Institute researchers are developing new immuno-materials, which help modulate immune cells to treat or diagnose disease. In this episode of Disruptive, Dave Mooney, Wyss Core Faculty...