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124 Results for 'Infectious Disease'
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Technologies 8
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Gene Drives
Since the 1940s, researchers have thought of using gene drives to eradicate populations of pests and disease vectors, and to reduce or eliminate invasive species that wreak havoc on natural ecosystems. The idea of a gene drive stems from nature itself, where in sexually reproducing organisms a certain version of a gene is preferentially passed... -
Manufacturing biomolecules ‘on the go’
Wyss Institute researchers have developed a biomolecular manufacturing method that can quickly and easily produce a wide range of vaccines, antimicrobial peptides and antibody conjugates while doing so anywhere, even in places without access to electrical power or refrigeration. The breakthrough could provide a life-saving workaround for making modern interventions available in remote areas. Today... -
Tethered Liquid Perfluorocarbon (TLP), a non-stick coating for medical devices
Every device implanted in the body or in contact with flowing blood faces two critical challenges that can threaten the life of the patient it is meant to help: blood clotting and bacterial infection. To confront this challenge, Wyss Institute researchers created a super-repellent, Thin Layer Perfluorocarbon (TLP) coating specifically designed to prevent clot formation... -
Implantable cancer vaccine
The Wyss Institute’s implantable, biodegradable cancer vaccine leverages immunotherapeutic methods and could one day help overcome melanoma, other cancers, infectious diseases, auto-immune diseases, as well as vaccinate against specific peptides, proteins, or antigens. The implant is a biodegradable polymer scaffold containing growth factors and components of each patient’s tumors. The technology was initially designed to... -
Pathogen Capture Technology for Infectious Disease Therapeutics and Diagnostics
Microbial contamination is the cause of life-threatening cases of sepsis, meningitis and multiple other infectious diseases that are a major cause of death world-wide. Equally prevalent are pathogenic contaminants in our environment, food, and manufacturing processes. In each case, the presence of microbial contaminants must be confirmed, and when they are found, they need to... -
Human Organs-on-Chips
Clinical studies take years to complete and testing a single compound can cost more than $2 billion. Meanwhile, innumerable animal lives are lost, and the process often fails to predict human responses because traditional animal models often do not accurately mimic human pathophysiology. For these reasons, there is a broad need for alternative ways to...
News 91
Multimedia 25
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Video/AnimationWyss Focus: Immuno-MaterialsWyss Core Faculty, Dave Mooney, explains our new Immuno-Materials Focus Area, which adds a new dimension to immunotherapy in that it harnesses materials to make treatments more efficient and effective. These material-based systems are capable of modulating immune cells and releasing them into the body where they can treat diseases. -
Video/AnimationToehold SwitchesIn this animation, Wyss Institute Postdoctoral Fellow Alex Green, Ph.D., the lead author of “Toehold Switches: De-Novo-Designed Regulators of Gene Expression”, narrates a step-by-step guide to the mechanism of the synthetic toehold switch gene regulator. Credit: Wyss Institute at Harvard University -
Video/AnimationIntroduction to Implantable Cancer VaccineWhat if we could prevent and treat cancer with a simple vaccine? Credit: Wyss Institute at Harvard University -
Video/AnimationIntroduction to Organs-on-a-ChipWhat if we could test drugs without animal models? Wyss Institute researchers and a multidisciplinary team of collaborators have engineered microchips that recapitulate the microarchitecture and functions of living human organs, including the lung, intestine, kidney, skin, bone marrow and blood-brain barrier. These microchips, called ‘organs-on-chips’, offer a potential alternative to traditional animal testing. Each... -
Video/AnimationSLIPS: Keeping Ice AwayWhat if we could design surfaces that prevent ice formation? ‘SLIPS’ technology, inspired by the slippery pitcher plant that repels almost every type of liquid and solid, is a unique approach to coating industrial and medical surfaces that is based on nano/microstructured porous material infused with a lubricating fluid. By locking in water and other... -
Video/AnimationSLIPS‘SLIPS’ technology, inspired by the slippery pitcher plant that repels almost every type of liquid and solid, is a unique approach to coating industrial and medical surfaces that is based on nano/microstructured porous material infused with a lubricating fluid. By locking in water and other fluids, SLIPS technology creates slick, exceptionally repellent and robust self-cleaning...