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Technologies 1

• abbieSense Anaphylaxis Diagnostic
  The molecule histamine plays a primary role in the anaphylaxis reaction, which is a major cause of illness and death in people with severe allergies. Histamine is a very small molecule composed of only seventeen atoms, making it a challenging target to detect. To date, no diagnostic test exists that can measure histamine levels accurately...

News 15

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• Awards Wyss Institute Receives Grant from Cystic Fibrosis Foundation
  October 17, 2018
• Press Release Lung cancer research gets a breath of fresh air
  October 10, 2017
• Press Release Wyss Institute’s Organ Chips get smart and go electric
  June 14, 2017

Multimedia 4

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  Video/Animation
  Smoking Human Lung Small Airway-on-a-Chip
  In this video, Wyss Founding Director Donald Ingber and Technology Development Fellow Kambez Benam explain how the integrated smoking device mimics normal cigarette smoke exposure and how it can impact research into the causes of COPD and into new biomarkers and therapeutics. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Small Airway-on-a-Chip: Modeling COPD and Asthma
  Development of new therapeutics for chronic lung diseases have been hindered by the inability to study them in vitro. To address this challenge, Wyss Institute researchers used their Organ-on-a-Chip technology to produce a microfluidic ‘human lung small airway-on-a-chip.’ The device, which is composed a clear rubber material, is lined by living Human lung small airway...

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  Video/Animation
  Researchers mimic pulmonary edema in Lung-on-a-Chip
  The Wyss Institute’s human breathing lung-on-a-chip, made using human lung and blood vessel cells, acts much like a lung in a human body. A vacuum re-creates the way the lungs physically expand and contract during breathing. As reported in Science Translational Medicine on November 7, 2012, Wyss researchers have now mimicked a human disease –...

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  Video/Animation
  Lung-on-a-Chip
  Combining microfabrication techniques with modern tissue engineering, lung-on-a-chip offers a new in vitro approach to drug screening by mimicking the complicated mechanical and biochemical behaviors of a human lung. This extended version of the video includes our findings when we mimicked pulmonary edema on the chip. Credit: Wyss Institute at Harvard University