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Technologies 5

• Metabolically Labeled CAR-T Cells Against Cancer
  Through a simple and effective metabolic labeling approach, patient-derived T cells engineered to carry immune-enhancing cytokines on their surfaces could help expand adoptive T cell therapies to treatment of solid tumors and improve blood cancer therapies.
• Cellular “Backpacks” to Fight Cancer, Autoimmune Disorders, and More
  Macrophages are very malleable immune cells, but that also means that they can be influenced by cancerous tumors and inflammatory processes. Our cellular "backpacks" stick to macrophages and can deliver molecules that keep them in their desired state for cell therapy and more.
• Catalytic Materials: Cheaper, Better Air Purification for a Healthier World
  Our catalytic materials are inspired by the nanostructure of butterfly wings and enable affordable air purification for a variety of applications.
• Nanoarchitectures for Air Purification
  Metalmark is using the Wyss Institute's butterfly-inspired nanoarchitecture coating to create air purification technology that can destroy airborne pollutants including chemicals, viruses, and smog at a fraction of the cost of current catalytic converter systems.
• NanoRx: Mechanically-Activated Drug Targeting
  The Wyss team has developed a novel drug targeting nanotechnology that is activated locally by mechanical forces, either endogenous high shear stresses in blood created by vascular occlusion or mechanical energy applied locally using low-energy ultrasound radiation. Today, vascular blockage is the leading cause of death and disability in United States and Europe. Current therapies...

News 18

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• Press Release
  
  ENTERing a new era of drug delivery
  May 15, 2025
• Community
  
  Vinny Chandran Suja on Making Backpacks More Reliable and Predictable
  August 20, 2024
• Press Release
  
  Empty “backpacks” activate the immune system against cancer
  March 19, 2024

Multimedia 3

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  Video/Animation
  Metabolic T cell Labeling: simple and effective enhancement of therapeutic T cells with immune-stimulating cytokines
  This animation shows how the surface of patient-derived T cells is metabolically labeled with azido-sugar molecules that then can be used to attach immune-enhancing cytokines with the help of click chemistry. The approach could help expand adoptive T cell therapies to treatment of solid tumors. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Catalytic Nanoarchitectures for Clean Air
  The Wyss Institute is developing a new type of coating for catalytic converters that, inspired by the nanoscale structure of a butterfly’s wing, can dramatically reduce the cost and improve the performance of air purification technologies, making them more accessible to all.  Credit: Wyss Institute at Harvard University  

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  Video/Animation
  NanoRx: Clot-Busting Nanotherapeutic
  In this animation, learn how the Wyss Institute clot-busting nanotherapeutic is activated by fluid high shear force – which occurs where blood flows through vessels narrowed by obstruction – to specifically target clots and dissolve them away. By pairing this drug with an intra-arterial device that restores blood flow to complete obstructions, the drug-device combination...