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Technologies 4

• Metabolically Labeled CAR-T Cells Against Cancer
  Through a simple and effective metabolic labeling approach, patient-derived T cells engineered to carry immune-enhancing cytokines on their surfaces could help expand adoptive T cell therapies to treatment of solid tumors and improve blood cancer therapies.
• Cellular “Backpacks” to Slow Tumor Growth
  A cell therapy innovation that keep macrophages activated against cancer. Macrophages are like little soldiers in our bodies that help fend off diseases like cancer. Our cellular “backpacks” are disc-shaped nanoparticles that can stick to a macrophage without being engulfed, and release a steady stream of cytokines into their macrophage “hosts” to help them fight against cancer.
• Nanoarchitectures for Air Purification
  Metalmark is using the Wyss Institute's butterfly-inspired nanoarchitecture coating to create air purification technology that can destroy airborne pollutants including chemicals, viruses, and smog in indoor and outdoor air at a fraction of the cost of current catalytic converter systems.
• NanoRx: Mechanically-Activated Drug Targeting
  The Wyss team has developed a novel drug targeting nanotechnology that is activated locally by mechanical forces, either endogenous high shear stresses in blood created by vascular occlusion or mechanical energy applied locally using low-energy ultrasound radiation. Today, vascular blockage is the leading cause of death and disability in United States and Europe. Current therapies...

News 14

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• Video/​Animation
  
  Giving old drugs new life…to save lives
  February 17, 2022
• Press Release
  
  Muscling up with nanoparticle-based anti-inflammatory therapy
  June 24, 2021
• Press Release
  
  Turning the problem of cancer metastasis into an opportunity
  November 16, 2020

Multimedia 3

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  Video/Animation
  Metabolic T cell Labeling: simple and effective enhancement of therapeutic T cells with immune-stimulating cytokines
  This animation shows how the surface of patient-derived T cells is metabolically labeled with azido-sugar molecules that then can be used to attach immune-enhancing cytokines with the help of click chemistry. The approach could help expand adoptive T cell therapies to treatment of solid tumors. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Catalytic Nanoarchitectures for Clean Air
  The Wyss Institute is developing a new type of coating for catalytic converters that, inspired by the nanoscale structure of a butterfly’s wing, can dramatically reduce the cost and improve the performance of air purification technologies, making them more accessible to all.  Credit: Wyss Institute at Harvard University  

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  Video/Animation
  NanoRx: Clot-Busting Nanotherapeutic
  In this animation, learn how the Wyss Institute clot-busting nanotherapeutic is activated by fluid high shear force – which occurs where blood flows through vessels narrowed by obstruction – to specifically target clots and dissolve them away. By pairing this drug with an intra-arterial device that restores blood flow to complete obstructions, the drug-device combination...