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Technologies 3

• DNA Nanoswitch Calipers for Single-Molecule Proteomics
  DNA nanoswitch calipers are a first-of-their-kind research tool that leverage DNA’s unique molecular qualities to study post-translational modifications on proteins to unlock a new frontier of medicine.
• Toehold Switches for Synthetic Biology
  The burgeoning field of synthetic biology is designing artificial gene circuits that recognize molecules in their environment and respond by regulating genes with desired activities. In the future, such capabilities could allow the engineering of cells as diagnostic or therapeutic devices, factories for the production of clinically or industrially coveted molecules, and as specialized devices...
• Multiplexed Molecular Force Spectroscopy
  Programmable DNA nanoswitches, invented at the Wyss Institute, can now be used in combination with a benchtop Centrifuge Force Microscope (CFM) as a highly reliable tool to observe thousands of individual molecules and their responses to mechanical forces in parallel. By analyzing the responses of single molecules under conditions where they experience such forces, it is possible...

News 5

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• Research Spotlights
  
  Hearing Acrobatics
  February 8, 2021
• Community
  
  9th Annual Wyss International Symposium: Molecular Robotics
  September 28, 2018
• Community
  
  Putting their heads together: when engineers and clinicians talk medicine
  September 27, 2018

Multimedia 1

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  Video/Animation
  DNA Nanoswitches
  Gel electrophoresis, a common laboratory process, sorts DNA or other small proteins by size and shape using electrical currents to move molecules through small pores in gel. The process can be combined with novel DNA nanoswitches, developed by Wyss Associate Faculty member Wesley Wong, to allow for the simple and inexpensive investigation of life’s most...