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Technologies 2

• PhonoGraft: 3D Printed Tympanic Membrane Graft
  Perforations of the tympanic membrane or “eardrum,” the thin membrane that conducts sound in the ear, can result in severe hearing loss and recurring infections. Worldwide, tympanic membrane perforations occur in about 30 million people, with about four million people in North America and the European Union alone, due to blast and other traumatic injuries,...
• Engineered Brain Organoids
  The ability to derive and manipulate pluripotent stem cells has opened up new avenues for modeling biological systems in both healthy and diseased conditions. In order to more fully recapitulate the tissue microenvironment with its cell-cell, cell-extracellular matrix, and cell-niche interactions, it is essential to transition stem-cell culturing from monolayers to 3D structures. Self-organization of...

News 13

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• Press Release
  
  A computational guide to lead cells down desired differentiation paths
  March 12, 2021
• Awards
  
  A Year in Review: 2020
  December 17, 2020
• Research Spotlights
  
  Editing genomes not dozens but thousands of times in one go
  May 12, 2020

Multimedia 5

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  Video/Animation
  PhonoGraft: Programming the eardrum to repair itself
  Eardrum perforations are a widespread problem affecting millions worldwide. Current standard of care is invasive, involves harvesting an autologous tissue to patch the eardrum, and often requires to revision surgeries, while hearing outcomes remain unsatisfying. What if we could program the eardrum to repair itself after injury? Researchers at the Wyss Institute, Massachusetts Eye and...

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  Video/Animation
  A Swifter Way Towards 3D-printed Organs
  20 people die waiting for an organ transplant every day in the US, but lab-grown organs so far lack the cellular density and functions required to make them viable replacements. The new SWIFT method from the Wyss Institute and Harvard SEAS solves those problems by 3D printing vascular channel networks directly into living tissue constructs,...

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  Video/Animation
  Origami Organs
  A multidisciplinary team of scientists, engineers, and architectural designers are developing Origami Organs that could function like artificial kidneys. Credit: Wyss Institute at Harvard University

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  Video/Animation
  This is Your Brain on Chips
  How do you study something as complex as the human brain? Take it apart. Wyss researchers have created Organ Chips that mimic the blood-brain barrier and the brain and, by linking them together, discovered how our blood vessels and our neurons influence each other. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Bioprinting: The Kidney’s Proximal Tubules
  In this video, see how the Wyss Institute team has advanced bioprinting to the point of being able to fabricate a functional subunit of a kidney. Credit: Wyss Institute at Harvard University