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Technologies 2

• Peptide-based drug delivery to target the brain
  The blood-brain-barrier (BBB) is a protective membrane that shields the brain from pathogens, toxins and large water-soluble molecules. Blood vessels throughout the body are lined by endothelial cells that allow some materials to flow from the blood stream into the surrounding tissues. In the brain however, the endothelial cells are more tightly coupled to prevent...
• Engineering organoids to recapitulate brain tissue
  The ability to derive and manipulate pluripotent stem cells has opened up new avenues for modeling biological systems in both healthy and diseased conditions. In order to more fully recapitulate the tissue microenvironment with its cell-cell, cell-extracellular matrix, and cell-niche interactions, it is essential to transition stem-cell culturing from monolayers to 3D structures. Self-organization of...

News 8

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• Research Spotlights Fewer steps in the lab, one more leap for organs-on-chips
  October 29, 2018
• Awards Wyss Institute Receives Grant from Cystic Fibrosis Foundation
  October 17, 2018
• Press Release Taking the brain apart to put it all together again
  August 20, 2018

Multimedia 2

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  Video/Animation
  This is Your Brain on Chips
  How do you study something as complex as the human brain? Take it apart. Wyss researchers have created Organ Chips that mimic the blood-brain barrier and the brain and, by linking them together, discovered how our blood vessels and our neurons influence each other. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Bioprinting: The Kidney’s Proximal Tubules
  In this video, see how the Wyss Institute team has advanced bioprinting to the point of being able to fabricate a functional subunit of a kidney. Credit: Wyss Institute at Harvard University