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Technologies 5

• Toehold Probes
  The accurate detection of specific DNA or RNA sequences is important for many research and diagnostic applications, and unspecific detection of similar sequences that can differ by only a single nucleotide can give false positive results. In addition, researchers and clinicians would like to accurately test for presence or absence of multiple single base changes...
• Toehold switches as versatile tools for synthetic biology applications
  The burgeoning field of synthetic biology is designing artificial gene circuits that recognize molecules in their environment and respond by regulating genes with desired activities. In the future, such capabilities could allow the engineering of cells as diagnostic or therapeutic devices, factories for the production of clinically or industrially coveted molecules, and as specialized devices...
• DNA Nanostructures for Drug Delivery
  Researchers at the Wyss Institute have developed two methods for building arbitrarily shaped nanostructures using DNA, with a focus on translating the technology towards nanofabrication and drug delivery applications. One proprietary nanofabrication technique, called “DNA-brick self-assembly,” uses short, synthetic strands of DNA that work like interlocking Lego® bricks. It capitalizes on the ability to program...
• Inexpensive Super-Resolution Microscopy
  Wyss Institute scientists have developed a highly versatile and inexpensive microscopic imaging platform designed to visualize objects with molecular-scale resolution and unprecedented complexity. The DNA-powered imaging technology can reveal the inner workings of cells at the single molecule level, using conventional microscopes found in most laboratories. Key to the Wyss Institute’s DNA-driven imaging super resolution...
• Paper-based synthetic gene networks as a new diagnostic approach
  With the imminent threat of new pandemics and frequent disease outbreaks exemplified by the recent Ebola and Zika epidemics, there is a growing need for low-cost, easily deployable and simple-to-use diagnostic tools. The Wyss Institute has developed paper-based synthetic gene networks as a next generation diagnostic technology for use in global healthcare crises and patient...

News 41

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• Research Spotlights Painting human chromosomes in 3D
  January 17, 2019
• Awards Wyss Institute Faculty member Peng Yin receives NIH Director’s Pioneer Award
  October 2, 2018
• Community 9th Annual Wyss International Symposium: Molecular Robotics
  September 28, 2018

Events 2

• Sep 21, 2018, 8:15am - 6:15pm Wyss Event
  
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  9th Annual Wyss International Symposium: Molecular Robotics
  The 9th International Wyss Symposium will focus on new advances in the emerging field of Molecular Robotics, with the goal of sharing recent progress at the intersection of DNA nanotechnology, synthetic biology, robotics, and computer science, that could lead to programmable molecular machines as novel solutions for research and medicine. This event is free, however... Free and open to public
• Jan 17, 2018, 1:00pm - 2:00pm Wyss Event
  
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  Error Correction Code (ECC) Sequencing – Can DNA Sequencing Be Error-free?
  Eliminating errors in next-generation DNA sequencing has proved challenging. Please join Professor Yanyi Huang as he discusses his team’s newly developed error-correction code (ECC) sequencing, a method to greatly improve sequencing accuracy. Combining fluorogenic sequencing-by-synthesis (SBS) with an information theory–based error-correction algorithm, ECC embeds redundancy in sequencing reads by creating three orthogonal degenerate sequences, generated... Free and open to public

Multimedia 13

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  Video/Animation
  Toehold Exchange Probes
  This animation explains how toehold probes consisting of a “probe strand” and a “protector strand” are assembled and how they leverage thermodynamic principles to allow the specific detection of a correct target sequence, or to prevent them from detecting a spurious target sequence that can differ from the correct target sequence by only a single...

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  Exchange-PAINT: Neurons Up Close and Personal
  DNA Exchange Imaging of fixed mouse hippocampal neurons stained sequentially with antibodies recognizing neuronal markers Synapsin I, vGAT, MAP2, pNFH, α-tubulin, acetyl-tubulin, GFAP and nuclear marker DAPI. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Primer Exchange Reaction
  In this video, Jocelyn Kishi illustrates how Primer Exchange Reaction (PER) cascades work to autonomously create programmable long single-stranded DNA molecules. Credit: Wyss Institute at Harvard University.

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  Video/Animation
  Auto-cyclic Proximity Recording
  This video explains how “Auto-cycling Proximity Recording” works to identify pairs of nearby molecular targets and how it can be used as a tool to decipher the geometry of 3-dimensional engineered and natural molecules. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Super Resolution Discrete Molecular Imaging Animation
  See in this animation, how Discrete Molecular Imaging (DMI) uses DNA nanotechnology to reveal densely packed molecular features in structures similar in size as single protein molecules. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Discrete Molecular Imaging
  Wyss Institute Core Faculty member Peng Yin and his co-worker Mingjie Dai explain in this video, how Discrete Molecular Imaging (DMI) can be used to enhance their DNA-PAINT super-resolution imaging platform to visualize features on a single-molecule scale. Credit: Wyss Institute at Harvard University