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76 Results for 'Peng Yin'
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Technologies 5
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Toehold Switches for Synthetic Biology
The burgeoning field of synthetic biology is designing artificial gene circuits that recognize molecules in their environment and respond by regulating genes with desired activities. In the future, such capabilities could allow the engineering of cells as diagnostic or therapeutic devices, factories for the production of clinically or industrially coveted molecules, and as specialized devices... -
Toehold Probes for Nucleic Acid Detection
The accurate detection of specific DNA or RNA sequences is important for many research and diagnostic applications, and unspecific detection of similar sequences that can differ by only a single nucleotide can give false positive results. In addition, researchers and clinicians would like to accurately test for presence or absence of multiple single base changes... -
DNA Nanostructures for Drug Delivery
Researchers at the Wyss Institute have developed two methods for building arbitrarily shaped nanostructures using DNA, with a focus on translating the technology towards nanofabrication and drug delivery applications. One proprietary nanofabrication technique, called “DNA-brick self-assembly,” uses short, synthetic strands of DNA that work like interlocking Lego® bricks. It capitalizes on the ability to program... -
Paper-Based Diagnostics
With the imminent threat of new pandemics and frequent disease outbreaks exemplified by the recent Ebola and Zika epidemics, there is a growing need for low-cost, easily deployable and simple-to-use diagnostic tools. The Wyss Institute has developed paper-based synthetic gene networks as a next generation diagnostic technology for use in global healthcare crises and patient... -
Inexpensive Super-Resolution Microscopy
Wyss Institute scientists have developed a highly versatile and inexpensive microscopic imaging platform designed to visualize objects with molecular-scale resolution and unprecedented complexity. The DNA-powered imaging technology can reveal the inner workings of cells at the single molecule level, using conventional microscopes found in most laboratories. Key to the Wyss Institute’s DNA-driven imaging super resolution...
News 51
Events 5
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Jan 6, 2020, 1:00pm - 2:00pmLecture
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Wyss Core Faculty member Peng Yin, Ph.D. is speaking as part of the Brigham and Women’s Hospital Pathology Grand Rounds on the topic of, “Super-resolution microscopy: A diagnostic tool in Pathology?” Dr. Yin is a Professor in the Department of Systems Biology at Harvard Medical School. His lab uses synthetic DNA/RNA to construct, manipulate, and... Free and open to public -
Sep 20, 2019, 8:20am - 6:00pmWyss Event
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The 10th International Wyss Institute Symposium will focus on Next-Generation Diagnostics; convening the Institute’s vast network of collaborators, students, researchers, faculty and clinicians alongside industrial researchers, and members of academic institutions and foundations leading the development of diagnostics technology. This year’s Symposium will highlight the latest developments of this emerging field and address the need... Free and open to public -
May 28, 2019, 1:00pm - 2:00pmLecture
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Wyss Core Faculty member Peng Yin will be speaking at a Brigham and Women’s Clinical Pathology Conference on Tuesday, May 28th from 1 PM to 2 PM. The topic is, “SABER enables amplified and multiplexed imaging of RNA/DNA and proteins in cells and tissues.” Directions Enter the main lobby of the Brigham and Women’s Hospital... Free and open to public
Multimedia 15
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Video/AnimationLighting up proteins with Immuno-SABERThis animation explains how Immuno-SABER uses the Primer Exchange Reaction (PER) to enable the simultaneous visualization of multiple proteins in tissues in different applications. Credit: Wyss Institute at Harvard University. -
Video/AnimationSABER-FISH: Enabling the sensitive and multiplexed detection of nucleic acids within thick tissuesThis animation shows how SABER-FISH uses a suite of DNA nanotechnological methods that together enable the sensitive and multiplexed detection of DNA and RNA targets within cells and thick tissues. Credit: Wyss Institute at Harvard University -
Video/AnimationToehold Exchange ProbesThis animation explains how toehold probes consisting of a “probe strand” and a “protector strand” are assembled and how they leverage thermodynamic principles to allow the specific detection of a correct target sequence, or to prevent them from detecting a spurious target sequence that can differ from the correct target sequence by only a single...
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Exchange-PAINT: Neurons Up Close and PersonalDNA Exchange Imaging of fixed mouse hippocampal neurons stained sequentially with antibodies recognizing neuronal markers Synapsin I, vGAT, MAP2, pNFH, α-tubulin, acetyl-tubulin, GFAP and nuclear marker DAPI. Credit: Wyss Institute at Harvard University -
Video/AnimationPrimer Exchange ReactionIn this video, Jocelyn Kishi illustrates how Primer Exchange Reaction (PER) cascades work to autonomously create programmable long single-stranded DNA molecules. Credit: Wyss Institute at Harvard University. -
Video/AnimationAuto-cyclic Proximity RecordingThis video explains how “Auto-cycling Proximity Recording” works to identify pairs of nearby molecular targets and how it can be used as a tool to decipher the geometry of 3-dimensional engineered and natural molecules. Credit: Wyss Institute at Harvard University