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Technologies 2

• Brain-Targeting Shuttles for Drug Delivery and Diagnostics
  In its Brain Targeting Program, a Wyss team led by Founding Director Donald Ingber, M.D., Ph.D. and Staff Program Lead James Gorman, M.D., Ph.D. is developing improved approaches to target drugs and diagnostics to the brain. Leveraging the human blood-brain barrier (BBB) Chip technology developed by Ingber’s team, combined with advanced antibody R&D capabilities, the...
• Engineered Brain Organoids
  The ability to derive and manipulate pluripotent stem cells has opened up new avenues for modeling biological systems in both healthy and diseased conditions. In order to more fully recapitulate the tissue microenvironment with its cell-cell, cell-extracellular matrix, and cell-niche interactions, it is essential to transition stem-cell culturing from monolayers to 3D structures. Self-organization of...

News 20

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• Press Release Investigating the human intestinal mucus barrier up-close and personal
  December 3, 2019
• Press Release Enhanced human Blood-Brain Barrier Chip performs in vivo-like drug and antibody transport
  June 13, 2019
• Press Release Engineered miniature kidneys come of age
  February 11, 2019

Multimedia 7

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  Video/Animation
  Kidney Organiods: Flow-Enhanced Vascularization and Maturation In Vitro
  This video explains how the collaborative project created vascularized kidney organoids and how they advance the field of tissue engineering. Credit: Wyss Institute at Harvard University.

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  Video/Animation
  New Wyss Institute Initiative – 3D Organ Engineering
  Wyss Institute Core Faculty members Christopher Chen and Jennifer Lewis describe the Wyss Institute’s new initiative focused on organ engineering, which leverages our expertise in biomaterials, tissue engineering, three dimensional biofabrication, and stem cell development.

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  Video/Animation
  Podocyte Cells: Kidney-on-a-Chip
  This video shows a 3-dimensional rendering of the glomerulus-on-a-chip with human stem cell-derived mature podocytes (in green) grown and differentiated in one channel (shown on top) and that extend their processes through the modeled glomerulus basement membrane towards glomerular vascular cells (in magenta) in the parallel running channel (shown on the bottom). Credit: Wyss Institute...

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  Video/Animation
  Efficient Recovery of Stem Cell Sheets
  See in this video how an intact sheet of mesenchymal stem cells, stained with a violet dye, can be lifted off the infused polymer substrate in the culture dish using a filter paper and transferred to a new surface. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Bioprinting: Building in Blood Vessels
  Building in blood vessels. Then they addressed a big challenge in tissue engineering: embedding 3D vascular networks. They developed a ‘fugitive’ ink that can easily be printed, then suctioned off to create open microchannels that can then be populated with blood-vessel-lining cells to allow blood to flow. Read more: wyss.harvard.edu/viewpressrelease/141 Credit: Wyss Institute at Harvard...

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  Video/Animation
  Bioprinting: Building with Bio-Inks
  Building with bio-inks. Using their custom-built printer, the fugitive ink for the vasculature, and other biological inks containing extracellular matrix and human cells, the researchers printed a 3D tissue construct. Credit: Wyss Institute at Harvard University