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Technologies 1

• Engineering organoids to recapitulate brain tissue
  The ability to derive and manipulate pluripotent stem cells has opened up new avenues for modeling biological systems in both healthy and diseased conditions. In order to more fully recapitulate the tissue microenvironment with its cell-cell, cell-extracellular matrix, and cell-niche interactions, it is essential to transition stem-cell culturing from monolayers to 3D structures. Self-organization of...

News 14

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• Translation News A vision of 3D Organ Engineering
  December 16, 2017
• Press Release Engineering human stem cells to model the kidney’s filtration barrier on a chip
  May 10, 2017
• Press Release David Mooney elected Fellow of the National Academy of Inventors
  December 13, 2016

Multimedia 6

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  Video/Animation
  New Wyss Institute Initiative – 3D Organ Engineering
  Wyss Institute Core Faculty members Christopher Chen and Jennifer Lewis describe the Wyss Institute’s new initiative focused on organ engineering, which leverages our expertise in biomaterials, tissue engineering, three dimensional biofabrication, and stem cell development.

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  Video/Animation
  Podocyte Cells: Kidney-on-a-Chip
  This video shows a 3-dimensional rendering of the glomerulus-on-a-chip with human stem cell-derived mature podocytes (in green) grown and differentiated in one channel (shown on top) and that extend their processes through the modeled glomerulus basement membrane towards glomerular vascular cells (in magenta) in the parallel running channel (shown on the bottom). Credit: Wyss Institute...

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  Video/Animation
  Efficient Recovery of Stem Cell Sheets
  See in this video how an intact sheet of mesenchymal stem cells, stained with a violet dye, can be lifted off the infused polymer substrate in the culture dish using a filter paper and transferred to a new surface. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Bioprinting: Building in Blood Vessels
  Building in blood vessels. Then they addressed a big challenge in tissue engineering: embedding 3D vascular networks. They developed a ‘fugitive’ ink that can easily be printed, then suctioned off to create open microchannels that can then be populated with blood-vessel-lining cells to allow blood to flow. Read more: wyss.harvard.edu/viewpressrelease/141 Credit: Wyss Institute at Harvard...

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  Video/Animation
  Bioprinting: Building with Bio-Inks
  Building with bio-inks. Using their custom-built printer, the fugitive ink for the vasculature, and other biological inks containing extracellular matrix and human cells, the researchers printed a 3D tissue construct. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Bioprinting: Building Intricate Structures
  Building intricate structures. The team first designed a custom printer that can precisely co-print multiple materials in 3D to create intricate heterogeneous patterns. Credit: Wyss Institute at Harvard University