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Technologies 5

• Sustained Growth Factor Delivery for Regenerating Tissues
  The Problem Millions of people worldwide suffer from traumatic injuries or health conditions that cause damage to soft tissues including nerves, muscles, and blood vessels. The body can heal some of that damage, but more serious cases like the severing of a nerve or sustained oxygen deprivation can lead to permanent loss of movement or...
• NanoRx: Mechanically-Activated Drug Targeting
  The Wyss team has developed a novel drug targeting nanotechnology that is activated locally by mechanical forces, either endogenous high shear stresses in blood created by vascular occlusion or mechanical energy applied locally using low-energy ultrasound radiation. Today, vascular blockage is the leading cause of death and disability in United States and Europe. Current therapies...
• Microfluidic Hemostasis Monitor
  The body’s ability to stop bleeding, also known as hemostasis, is critical for survival. For patients with blood clotting disorders, medical conditions requiring the use of anticoagulation or antiplatelet drugs, or who require treatment with extracorporeal devices that circulate their blood outside of the body, it is essential that care providers can rapidly monitor their...
• 3D Bioprinting of Living Tissues
  Progress in drug testing and regenerative medicine could greatly benefit from laboratory-engineered human tissues built of a variety of cell types with precise 3D architecture. But production of greater than millimeter sized human tissues has been limited by a lack of methods for building tissues with embedded life-sustaining vascular networks. In this video, the Wyss...
• Human Organs-on-Chips
  Organ Chips are microfluidic devices lined with living human cells for drug development, disease modeling, and personalized medicine. Launched in 2014, Wyss startup Emulate, Inc., is leveraging the Wyss Institute’s Organ Chip technology to mimic human organs in vitro, enabling faster, better, and cheaper drug development and insights into human health.

News 22

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• Translation News
  
  Alkem licenses technology from Harvard University, aiming to treat ischemic injury and vascular diseases
  February 10, 2022
• Research Spotlights
  
  An ionic forcefield for nanoparticles
  November 25, 2020
• Press Release
  
  Human Body-on-Chip platform enables in vitro prediction of drug behaviors in humans
  January 27, 2020

Multimedia 14

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  Video/Animation
  Alginate Hydrogel for Angiogenesis
  This video describes how an alginate hydrogel can be used to trigger the formation of new blood vessels at an ischemic site in the body. Credit: Wyss Institute at Harvard University.

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  Video/Animation
  Interrogator: Human Organ-on-Chips
  This video describes the “Interrogator” instrument that can be programmed to culture up to 10 different Organ Chips and sequentially transfer fluids between their vascular channels to mimic normal human blood flow between the different organs of our body. Its integrated microscope enables the continuous monitoring of the tissues’ integrities in the individual organ chips...

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  Video/Animation
  A Swifter Way Towards 3D-printed Organs
  20 people die waiting for an organ transplant every day in the US, but lab-grown organs so far lack the cellular density and functions required to make them viable replacements. The new SWIFT method from the Wyss Institute and Harvard SEAS solves those problems by 3D printing vascular channel networks directly into living tissue constructs,...

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  Video/Animation
  New Wyss Institute Initiative – 3D Organ Engineering
  Wyss Institute Core Faculty members Christopher Chen and Jennifer Lewis describe the Wyss Institute’s new initiative focused on organ engineering, which leverages our expertise in biomaterials, tissue engineering, three dimensional biofabrication, and stem cell development.

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  Video/Animation
  Therapeutic Organ Engineering: Highlights From The 8th Annual Wyss Symposium
  The 8th Annual Wyss International Symposium focused on innovations in therapeutic organ engineering, featuring diverse speakers doing exciting work in 3D organ engineering, materials fabrication, and vascular integration. This video highlights some of the themes discussed in their presentations as well as the advances that are leading to the ultimate goals of developing new approaches...

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  Video/Animation
  8th Annual Wyss Institute Symposium: Therapeutic Organ Engineering
  Screened just before the symposium opening, this animation artistically connects concepts of therapeutic organ engineering presented during the event. Credit: Wyss Institute at Harvard University